EPIDERMAL CHANGES IN HUMAN-SKIN FOLLOWING IRRADIATION WITH EITHER UVB OR UVA
EPIDERMAL CHANGES IN HUMAN-SKIN FOLLOWING IRRADIATION WITH EITHER UVB OR UVA
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DOI：
10.1111/1523-1747.ep12465094
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发表时间：
1987-01-01
影响因子：
6.5
通讯作者：
MARKS, R
中科院分区：
文献类型：
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作者：
PEARSE, AD;GASKELL, SA;MARKS, R
我们以前已经证明，UVB照射后，正常志愿者的表皮和角质层厚度增加，胸苷放射自显影标记指数增加。这些变化与表皮葡萄糖-6-磷酸脱氢酶和琥珀酸脱氢酶活性的改变相结合，尽管临床上没有红斑。使用防晒霜并不能完全防止这些变化。在这项研究中，我们研究了重复照射的影响，无论是UVB或UVA单独的人皮肤，以比较在表皮产生的变化，并确定是否UVA照射可能会导致这些。发现单独用UVB或UVA照射可显著增加平均表皮厚度、平均角质层厚度和平均角质形成细胞高度。葡萄糖-6-磷酸脱氢酶活性显着增加整个表皮，琥珀酸脱氢酶活性显着下降。UVB照射后放射自显影标记指数显著增加，但UVA照射后无显著增加。这些结果表明，单独的UVA可以对表皮形态和代谢产生直接影响，这表明保护皮肤免受UV辐射应包括充分保护免受UVA。
We have demonstrated previously that following UVB irradiation to normal volunteers there is an increase in epidermal and stratum corneum thickness and an increase in the thymidine autoradiographic labeling index. These changes are coupled with alterations in epidermal glucose-6-phosphate dehydrogenase and succinic dehydrogenase activities, despite the absence of erythema clinically. The use of a sunscreen did not completely prevent these changes. In this study, we have examined the effects of repeated irradiation of human skin with either UVB or UVA alone in order to compare the changes produced in the epidermis and to ascertain whether UVA irradiation could cause these. Irradiation with either UVB or UVA alone was found to increase the mean epidermal thickness, the mean stratum corneum thickness, and mean keratinocyte height significantly. Glucose-6-phosphate dehydrogenase activity was significantly increased throughout the epidermis, and succinic dehydrogenase activity was significantly decreased. The autoradiographic labeling index was significantly increased following UVB irradiation but not following UVA irradiation. These results demonstrate that UVA alone can have a direct effect on epidermal morphology and metabolism, suggesting that protection of skin from UV radiation should include adequate protection from UVA.