What is the optimal management for preventing saphenous vein graft diseases? Early results of intravascular angioscopic assessment
What is the optimal management for preventing saphenous vein graft diseases? Early results of intravascular angioscopic assessment
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DOI：
10.1253/circj.71.286
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发表时间：
2007-02-01
影响因子：
3.3
通讯作者：
Minami, Kazutomo
中科院分区：
文献类型：
--
作者：
Hata, Mitsumasa;Sezai, Akira;Minami, Kazutomo
背景冠状动脉搭桥术后大隐静脉移植物（SVG）早期失效的主要机制尚不清楚，因此血管镜检查被用于识别SVG。方法和结果在评估的31个SVG中，15个具有黄色斑块和血栓，而在其余16个SVG中，内膜是透明的白色。SVG组血清低密度脂蛋白胆固醇水平明显高于对照组。8例正常SVG组患者处方噻氯匹定，相比之下，只有1例从患病SVG组（p = 0.015）。结论这是第一次直接演示黄色斑块和/或血栓形成的SVG血管内血管镜检查。除了处方他汀类药物的重要性外，在阿司匹林治疗中加入噻氯匹定也可能至关重要。
Background The predominant mechanism of early failure of saphenous vein grafts (SVG) after coronary bypass remains unclear, so angioscopy was used to identify the. morphological changes.Methods and Results Of the 31 SVGs assessed 15 had both yellow plaque and thrombi, whereas in the remaining 16 SVGs the intima was clear white. The serum low-density lipoprotein cholesterol level was significantly higher in the diseased SVG group. Eight patients of the normal SVG group were prescribed ticlopidine, compared with only 1 from the diseased SVG group (p = 0.015).Conclusions This is the first direct demonstration of yellow plaque and/or thrombosis in SVGs by intravascular angioscopy. In addition to the importance of prescribing statins, it might be vital to also add ticlopidine to aspirin therapy.