Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery
Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery
复制标题
氧化还原双敏感多嵌段共聚物囊泡，具有二硫键连续给药功能
DOI：
10.1039/d2tb02686d
复制
发表时间：
2023-02-03
影响因子：
7
通讯作者：
Ding, Mingming
中科院分区：
文献类型：
--
作者：
Cheng, Cheng;Ma, Jiayun;Ding, Mingming
基于富含二硫键的多嵌段共聚物囊泡，我们提出了一种简单的顺序给药系统，具有双重氧化还原反应，分别在氧化和还原条件下释放亲水性盐酸多柔比星（DOX中心点HCl）和疏水性紫杉醇（PTX）。当与同时治疗递送相比时，药物释放的时空控制允许改善的组合抗肿瘤作用。这种结构简单、智能化的纳米载体在肿瘤治疗领域具有广阔的应用前景。
Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX center dot HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.