Duodenal ulcers: early and late onset.
Duodenal ulcers: early and late onset.
复制标题
十二指肠溃疡：早发和晚发。
作者：
Shiu Kum;G. B. Ong;B. LamG.;Ong
本文对我院1042例十二指肠溃疡患者进行了系列检查，以确定溃疡消化不良发病年龄与血型及溃疡消化不良家族史的关系。研究发现，在20岁前出现症状的患者（早发型患者）中，a、B、AB型患者所占比例明显大于在40岁以后出现症状的患者（晚发型患者），其消化不良家族史明显较强，后者以O型血为主。O组状态与十二指肠溃疡的显著易感性和出血的显著易感性相关，在晚发患者中，复发性和重度出血的显著易感性相关。出血是早期发病患者的主要并发症。迟发性溃疡出现穿孔、狭窄、剧烈疼痛和剧毒（即多发、球囊后或巨大）的趋势明显增加。虽然这些特征似乎与衰老的影响无关，但相关胃溃疡的发生与死亡率显示出相关性。
A hospital series of 1042 duodenal ulcer patients was examined to determine the relationship of the age of onset of ulcer dyspepsia with the blood group and with the family history of ulcer dyspepsia. It was found that those patients whose symptoms begin in the first two decades of life (early onset patients) contain a significantly larger proportion of group A, B, and AB subjects and a significantly stronger family history of dyspepsia than those whose symptoms begin from the fourth decade of life onwards (late onset patients), in whom blood group O prevails. The group O status is shown to be associated with a significant proneness to duodenal ulceration and a significant proneness to bleed, and in the late onset patients a significant proneness to bleed recurrently and severely. Bleeding is the predominent complication in the early onset patients. There is a significantly increased tendency for the late onset ulcers to perforate, to become stenosed, to have severe pain, and to be virulent--that is, to be multiple, post-bulbar, or giant. While these features do not appear to be related to the effect of ageing, the occurrence of associated gastric ulceration and the mortality rate was shown to be related.