Translation Elongation and Recoding in Eukaryotes.

Translation Elongation and Recoding in Eukaryotes.
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DOI:
10.1101/cshperspect.a032649
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发表时间:
2018-08-01
影响因子:
7.2
通讯作者:
Green R
Green R
中科院分区:
生物学1区
文献类型:
--
作者:
Dever TE;Dinman JD;Green R

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在这篇综述中,我们重点介绍了目前对真核生物翻译延伸和重新编码的理解。除了概述这一过程外,本文还讨论了我们对因子eIF5A在翻译延伸和翻译终止中的作用的理解的最新进展。我们还强调了翻译重新编码的机制,重点是核糖体在延伸期间的移框。我们看到延伸的基本步骤和不太常见的重新编码事件之间的平衡是由不同过程的动力学以及特定的序列决定因素决定的。
In this review, we highlight the current understanding of translation elongation and recoding in eukaryotes. In addition to providing an overview of the process, recent advances in our understanding of the role of the factor eIF5A in both translation elongation and termination is discussed. We also highlight mechanisms of translation recoding with a focus on ribosomal frameshifting during elongation. We see that the balance between the basic steps in elongation and the less common recoding events is determined by the kinetics of the different processes as well as by specific sequence determinants.
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