Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging
Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging
复制标题
相位校正磁化率加权成像显示以帕金森病为主的多系统萎缩和特发性帕金森病的不同铁沉积模式
DOI：
10.3174/ajnr.a2765
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发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
Xu, H.
中科院分区：
文献类型：
--
作者：
Wang, Y.;Butros, S. R.;Xu, H.
背景和目的：MSA-P和IPD具有相似的临床表现，可能使准确的临床诊断复杂化。组织病理学检查证实这两种疾病的铁沉积模式不同。目的是证明不同的铁沉积模式的MSA-P和（PD通过使用SW）phase images.MATERIALS和METHODS：16例IPD患者，8与MSA-P，和44名年龄匹配的健康对照进行SWI的大脑。对几个灰核中不同的相移以及高铁百分比区域进行了统计学评估。结果：MSA-P患者的壳核和PT铁沉积明显高于IPD患者（P <0.05）。此外，ROC曲线表明，通过高铁沉积百分比面积比平均相移（壳核：AUC = 0.88 vs 0.78; PT：AUC = 0.79 vs 0.62），区分MSA-P和IPD的灵敏度略高。此外，壳核内下区是鉴别MSA-P和MSA-P最有价值的亚区，（4个亚区之间的PD（高铁百分比面积和平均相移的AUC分别为0.92和0.91）。壳核和PT中较高的铁沉积可以将MSA-P与（PD，但壳核的下内区可能比PT和壳核的其他亚区更好。此外，与平均相移相比，高铁百分比使得可以更可靠地检测铁含量的较小增加。
BACKGROUND AND PURPOSE: MSA-P and IPD have similar clinical presentations that may complicate accurate clinical diagnosis. Different iron-deposition patterns of those 2 diseases have been demonstrated in histopathology. The aim was to demonstrate the different iron-deposition patterns of MSA-P and (PD by using SW) phase images.MATERIALS AND METHODS: Sixteen patients with IPD, 8 with MSA-P, and 44 age-matched healthy controls underwent SWI of brain. The different phase shifts as well as the high iron percentage of the area in several gray nuclei were statistically evaluated. The putamen was divided into 4 subregions for further analysis.RESULTS: Patients with MSA-P had significantly higher iron deposition in the putamen and PT compared with those with IPD (P < .05). Moreover, ROC curves indicated slightly more sensitivity in differentiating MSA-P from IPD, by means of the high-iron-deposition-percentage area than the average phase shift (putamen: AUC = 0.88 versus 0.78; PT: AUC = 0.79 versus 0.62). Moreover, the lower inner region of the putamen was the most valuable subregion in differentiating MSA-P from (PD among the 4 subregions (AUC = 0.92 and 0.91 for high-iron-percentage area and average phase shift, respectively).CONCLUSIONS: Higher iron deposition in the putamen and PT may differentiate MSA-P from (PD, but the lower inner region of the putamen may be better compared with the PT and other subregions of the putamen. Moreover, the high iron percentage makes it possible to detect smaller increases in iron content more confidently in comparison with average phase shift.