The Role of the Golgi-Resident SPCA Ca2+/Mn2+ Pump in Ionic Homeostasis and Neural Function
The Role of the Golgi-Resident SPCA Ca2+/Mn2+ Pump in Ionic Homeostasis and Neural Function
复制标题
高尔基体 SPCA Ca2 /Mn2 泵在离子稳态和神经功能中的作用
DOI：
10.1007/s11064-011-0644-6
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发表时间：
2012-03-01
影响因子：
4.4
通讯作者：
Hu, Zhiping
中科院分区：
文献类型：
--
作者：
He, Wenfang;Hu, Zhiping
最近的证据强调了高尔基体(GA)在神经系统疾病中的功能重要性。哺乳动物GA的功能除了处理和运输货物外，还包括离子动态平衡。除了作为激动剂敏感的细胞内钙⁺储存库的钙离子释放通道和钙离子结合蛋白外，赤霉酸还含有钙摄取机制，包括众所周知的肌内质网钙⁺转运酶和少有特色的分泌途径钙⁺转运酶(SPCA)。SPCA可以将钙⁺和锰⁺转运到高尔基体腔内，从而参与细胞内和高尔基体内钙⁺和锰⁺的动态平衡。研究表明，SPCAs的mRNA和蛋白在脑内均有高表达。此外，脑是SPCa亚型活性最高的区域，这可能与钙⁺和锰⁺的动态平衡参与神经功能有关。在这篇综述中，我们汇编了一些最新的发现，表明SPCA亚型在细胞内离子平衡中发挥着比先前预期更重要的作用，并阐明了SPCA亚型参与了某些神经生理或神经病理过程。我们有兴趣深入了解SPCA泵的复杂作用，以解释GA在神经疾病中的特定功能。
Recent evidence highlights the functional importance of the Golgi apparatus (GA) in neurological diseases. The functions of the mammalian GA, in addition to the processing and transport of cargo, also include ionic homeostasis. Besides Ca²⁺-release channels which serves GA as an agonist-sensitive intracellular Ca²⁺ store, and Ca²⁺-binding proteins, the GA contains Ca²⁺-uptake mechanisms consisting of the well-known sarco-endoplasmic reticulum Ca²⁺-transport ATPases and the much less characterized secretory-pathway Ca²⁺-transport ATPases (SPCA). SPCA can transport both Ca²⁺ and Mn²⁺ into the Golgi lumen and therefore is involved in the cytosolic and intra-Golgi Ca²⁺ and Mn²⁺ homeostasis. It has shown that both of the mRNA and protein of SPCAs are highly expressed in brain. In addition, brain is the region with the highest activity of SPCA isoforms, which may be related to the involvement of Ca²⁺ and Mn²⁺ homeostasis in neural functions. In this review, we compile some recent findings showing that the SPCA isoform plays a much more important role in intracellular ionic homeostasis than previously anticipated and illustrating the involvement of SPCA isoforms in certain neurophysiological or neuropathological process. We are interested in gaining insight into the intricate role of the SPCA pumps to explain the GA-specific functions in neurological disorders.