Turing patterning with and without a global wave
Turing patterning with and without a global wave
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DOI：
10.1371/journal.pbio.3000195
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发表时间：
2019-03-01
期刊：
影响因子：
9.8
通讯作者：
Chuong Cheng-Ming
中科院分区：
文献类型：
--
作者：
Inaba, Masafumi;Harn, Hans I-Chen;Chuong Cheng-Ming
周期性图案化是组织形态发生中的一个基本过程。在鸡的背部皮肤中，羽毛的形成从中线开始，然后形态发生波双向传播，留下规则的六角形羽毛细菌阵列。然而，体外重建显示羽毛细菌同时出现，这导致了一种假设，即羽毛形成波是局部图灵图案化过程和一个未知的全球事件耦合的结果。在这一期中，Ho和他的同事们展示了这样一个在鸡毛中发生的全球性事件，涉及到传播的外周血球蛋白A(EDA)波和成纤维细胞生长因子20(FGF20)-基于细胞聚集体的机械力化学偶联。在不会飞的鸟类中，羽毛细菌周期性地形成，但由于缺乏全球波，没有精确的六角形图案。
Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.