Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trial
Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trial
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DOI：
10.1111/bjh.12185
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发表时间：
2013-03-01
影响因子：
6.5
通讯作者：
Figueiredo, Maria S.
中科院分区：
文献类型：
--
作者：
Arruda, Martha M.;Mecabo, Grazielle;Figueiredo, Maria S.
Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. The use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA patients, patients over 18years were randomly assigned to receive VitC 1400mg+VitE 800mg per day or placebo orally for 180d. Eighty-three patients were enrolled (44 vitamins, 39 placebo), median age 27 (1868) years, 64% female. There were no significant differences between the two groups regarding clinical complications or baseline laboratorial tests. Sixty percent of the patients were VitC deficient, 70% were VitE deficient. Supplementation significantly increased serum VitC and E. However, no significant changes in haemoglobin levels were observed, and, unexpectedly, there was a significant increase in haemolytic markers with vitamin supplementation. In conclusion, VitC+VitE supplementation did not improve anaemia and, surprisingly, increased markers of haemolysis in patients with SCA and S-0-thalassaemia. The exact mechanisms to explain this findings and their clinical significance remain to be determined.
