Wireless gastric stimulators
Wireless gastric stimulators
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无线胃刺激器
DOI：
10.1109/wmcas.2014.7015875
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
J. Chiao
中科院分区：
文献类型：
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作者：
Smitha M. N. Rao;Souvik Dubey;S. Deb;Z. Hughes;Young;M. Nguyen;Shou;T. Abell;C. Lahr;J. Chiao
包括胃轻瘫在内的胃动力障碍会导致慢性衰弱症状。胃电刺激（GES）已被证明对胃起搏、胃排空和治疗胃节律失常有效。然而，当前基于电池的 GES 设备体积庞大且使用寿命有限。装置植入需要进行大手术。在本文中，我们提出了微型无线胃电刺激器来克服现有的缺点。基于可充电电池和无电池的刺激器在台式实验和活体猪动物模型中进行了测试。基于电池的系统利用无线充电，而无电池设备则收集电磁能来为向组织传送电脉冲的微控制器供电。两个原型都在三种不同的刺激设置下进行了测试以进行演示。记录的胃电图（EGG）在信号幅度、频率、刺激功率和能量方面进行分析。分析了 GES 期间的 EGG 频率变化、振幅比和胃节律活动。结果表明，无线微型刺激器改变了胃节律活动。使用这些微型设备可以消除重复进行电池更换手术的需要。刺激器的小尺寸也使得通过内窥镜手术植入它们成为可能。
Gastric dysmotility disorders including gastroparesis cause chronic debilitating symptoms. Gastric electrical stimulation (GES) has shown to be effective in stomach pacing, gastric emptying and treating gastric dysrhythmia. However, the current battery-based GES devices are bulky yet with limited lifetime. The device implantation requires a major surgery. In this paper, we present miniature wireless gastric electrical stimulators to overcome the existing shortcomings. Rechargeable battery based and batteryless stimulators were tested in benchtop experiments and live porcine animal models. The battery-based system utilizes wireless charging while the batteryless device harvests electromagnetic energy to power a microcontroller that delivers electrical pulses to tissues. Both prototypes were tested at three different stimulation settings for demonstration. Recorded electrogastrograms (EGG) in stomach were analyzed in terms of signal amplitude, frequency, stimulation power and energy. EGG frequency variations, amplitude ratios, and gastric rhythmic activities during GES were analyzed. The results showed that the wireless miniature stimulators modified gastric rhythmic activities. Utilization of these miniature devices may eliminate the need of repeated surgeries for battery replacement. The small size of the stimulators also makes it feasible to implant them through endoscopic surgeries.