Arterial stiffness index as a screening test for cardiovascular risk: a comparative study between coronary artery calcification determined by electron beam tomography and arterial stiffness index determined by a VitalVision device in asymptomatic subjects.
Arterial stiffness index as a screening test for cardiovascular risk: a comparative study between coronary artery calcification determined by electron beam tomography and arterial stiffness index determined by a VitalVision device in asymptomatic subjects.
复制标题
DOI：
10.1016/j.ejim.2005.06.011
复制
发表时间：
2005-12-01
影响因子：
8
通讯作者：
Seref, Besim
中科院分区：
文献类型：
--
作者：
Altunkan, Sekip;Oztas, Kamuran;Seref, Besim
背景：动脉僵硬最近被认为是心血管疾病的一个强有力的独立预测因子。然而，动脉硬化对心脏和大血管之间的相互作用和动脉粥样硬化的影响尚不清楚。动脉僵硬指数(ASI)是最近用一种新的设备(VitalVision)测定的，它使用计算机振荡法计算上臂的ASI。冠状动脉钙化(CAC)是电子束断层扫描(EBT)无创检测冠状动脉病变的有效替代指标。方法：对97例无症状患者在同一天分别用EBT和VITALVISION仪器测定CAC和ASI。钙化积分大于0者为CAC+，钙化积分等于0者为CAC-。根据VitalVision设备提供的H值将ASI指数分为轻度、中度和高度三组。结果：在51岁以下的患者中，ASI与CAC之间没有相关性。在50岁以上的患者中，颈动脉计分与动脉粥样硬化指数之间存在中度正相关(r=0.4，p=0.001)。结论：50岁以上患者颈动脉颈动脉积分与动脉粥样硬化指数之间存在相关性，表明动脉粥样硬化指数可用于动脉粥样硬化风险的研究。
BACKGROUND: Arterial stiffness has recently been proposed as a powerful independent predictor of cardiovascular disease. However, the influence of arterial stiffening on the interaction between the heart and large vessels and atherosclerosis is not well defined. The arterial stiffness index (ASI) has recently been determined with a new device (VitalVision) that calculates ASI in the upper arm using computerized oscillometry. Coronary artery calcification (CAC) is a useful surrogate marker of coronary artery disease detected non-invasively by electron beam tomography (EBT). We investigated the correlation between ASI and CAC in a group of patients.METHODS: CAC and ASI measurements were determined with EBT and a VitalVision device, respectively, on the same day in 97 asymptomatic patients. Patients with calcium scores above 0 were classified as CAC+ and those with calcium scores equal to 0 were classified as CAC-. The ASI index was divided into three groups - mild, moderate, and high - according to the H-value, provided by the VitalVision device.RESULTS: In patients below 51 years of age, no correlation between the ASI and CAC was found. In patients over 50 years of age, a moderate positive and significant correlation was found between the CAC score and ASI measurements (r=0.40, p=0.001).CONCLUSIONS: The presence of a correlation between the CAC and ASI in patients over 50 shows that the ASI can be used to investigate atherosclerotic risk.