Long-term effect of deep brain stimulation for essential tremor on activities of daily living and health-related quality of life
Long-term effect of deep brain stimulation for essential tremor on activities of daily living and health-related quality of life
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DOI：
10.1111/j.1600-0404.2008.01065.x
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发表时间：
2008-12-01
影响因子：
3.5
通讯作者：
Koskinen, L.-O. D.
中科院分区：
文献类型：
--
作者：
Hariz, G.-M.;Blomstedt, P.;Koskinen, L.-O. D.
报告丘脑深部脑刺激（DBS）对特发性震颤（ET）患者日常生活活动（ADL）和健康相关生活质量（HRQoL）的长期影响。连续19例患者分别在基线、平均1年和DBS后平均7年采用震颤评定量表、迷你精神测试、ADL分类法、诺丁汉健康概况、生活满意度检查表、视觉模拟量表和访谈进行评估。术后1 ~ 7年DBS治疗震颤的效果有所下降。除进食能力外，1年ADL的显著改善不再长期持续。社会生活继续改善。尽管DBS在7岁时对震颤的影响有所下降，尽管进一步的衰老和合并症可能会影响患者的幸福感，但DBS在ET患者的ADL和HRQoL的一些方面仍然有相关的益处。
To report long-term effects of thalamic deep brain stimulation (DBS) on activities of daily living (ADL) and health-related quality of life (HRQoL) in patients with essential tremor (ET).Nineteen consecutive patients were evaluated at baseline, at a mean of 1 year, then at a mean of 7 years after DBS using Tremor Rating Scale, Mini Mental Test, ADL Taxonomy, Nottingham Health Profile, Life Satisfaction Checklist, Visual Analogue Scale and interview.There was a decrease of DBS efficacy on tremor between 1 and 7 years post-operatively. The marked improvement in ADL at 1 year was no longer sustained at long-term, except for the ability to eat. Social life remained improved.Although there is a decrease of DBS effect on tremor at 7 years, and even though further ageing and co-morbidities may impact on the well-being of patients, there is still relevant benefit of DBS on few aspects of ADL and HRQoL in patients with ET.