[Nonexpressor of pathogenesis-related genes 1 (NPR1): a key node of plant disease resistance signalling network].
[Nonexpressor of pathogenesis-related genes 1 (NPR1): a key node of plant disease resistance signalling network].
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发表时间：
2005-07
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通讯作者：
Hong-Zhi Zhang;Xin-Zhong Cai
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作者：
Hong-Zhi Zhang;Xin-Zhong Cai
NPRI （nonexpressor of致病相关基因(1)）基因首次在拟南芥（Arabidopsis thaliana）中克隆，是参与植物抗病调控的关键基因。它不仅在全身性获得性耐药（SAR）和诱导全身性耐药（ISR）中起关键作用，而且在基础耐药和耐药(R)基因依赖性耐药中也起关键作用。氧化破裂后还原条件增强导致的NPR1单体化，以及NPR1单体在细胞核内的积累，是PR（致病相关）基因和SAR表达的必要条件和充分条件。NPR1通过与TGA转录因子（TF）相互作用调控PR基因的表达。作为多种防御信号通路的交叉点，NPR1可能通过直接或间接与一些WRKY TFs和NPR1样蛋白NPR4相互作用，在平衡水杨酸和jasmonic酸依赖的信号转导通路中至关重要，这是通过细胞质中未知的机制实现的。本文还对NPR1在植物保护中的应用前景进行了展望。
The NPRI (nonexpressor of pathogenesis-related genes (1) gene, firstly cloned in Arabidopsis thaliana, is a key gene involved in regulation of plant disease resistance. It plays a pivotal role not only in systemic acquired resistance (SAR) and induced systemic resistance (ISR), but also in basic resistance and resistance (R) gene-dependent resistance. NPR1 monomerization induced by enhanced reducing condition after oxidative burst, and the accumulation of NPR1 monomers in the nuclei, are required and enough for expression of PR (pathogenesis-related) genes and SAR. NPR1 regulates PR gene expression through interaction with TGA transcription factors (TF). As a cross-talk point of a variety of defense signaling pathways, probably through direct or indirect interacting with some WRKY TFs and a NPR1-like protein NPR4, NPR1 is essential in balancing salicylic acid- and jasmonic acid- dependent signal transduction pathways, which is achieved through an unknown mechanism in the cytosol. The possible application of NPR1 in plant protection is also discussed in this review.