High hepatic natural killer cell activity in murine lupus
High hepatic natural killer cell activity in murine lupus
复制标题
小鼠狼疮中肝脏自然杀伤细胞活性高
DOI：
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发表时间：
1987
影响因子：
15.3
通讯作者：
S. Latta
中科院分区：
文献类型：
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作者：
D. Magilavy;A. Steinberg;S. Latta
本研究证明了NK活性的显著升高，如通过在4小时孵育51 Cr-释放测定中对YAC-1靶标的细胞毒性所测量的，来自MRL/lpr和（NZB X NZW）F1小鼠的新鲜分离的肝NPC。在脾脏或外周血NK中未观察到这种显著增加。肝脏NK细胞为非粘附性、放射抵抗性、Ly-1-、2-和AGM 1+。此外，生物反应调节剂可以进一步增强这些自身免疫菌株中的肝脏NK活性。
This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr- release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The hepatic NK were nonadherent, radioresistant, Ly-1-,2-, and AGM1+. Furthermore, biologic response modifiers can further augment hepatic NK activity in these autoimmune strains.