Disulfiram-induced hypothermia in the normal rat; its attenuation by pimozide
Disulfiram-induced hypothermia in the normal rat; its attenuation by pimozide
复制标题
双硫仑引起的正常大鼠体温过低；
DOI：
10.1016/0028-3908(78)90013-8
复制
发表时间：
1978
影响因子：
4.7
通讯作者：
D. Cianflone
中科院分区：
文献类型：
--
作者：
M. Sharkawi;D. Cianflone
正常大鼠腹腔注射双硫仑（一种多巴胺-β-羟化酶抑制剂（DβHI））会产生剂量依赖性体温过低，匹莫齐特（一种多巴胺受体选择性阻断剂）可显着降低体温。正常大鼠腹腔注射另一种 DßHI（甲硫咪唑）也会产生体温过低，匹莫齐特可显着降低体温。这些实验表明，当全身给予双硫仑时，双硫仑能够使正常大鼠体温降低。匹莫齐特显着降低双硫仑或他巴唑引起的体温过低的事实表明，这种体温过低反应可能涉及多巴胺受体的激活。
Intraperitoneal injection of disulfiram, a dopamine-β-hydroxylase inhibitor (DβHI), in normal rats produced a dose-dependent hypothermia which was significantly reduced by pimozide, a selective blocker of dopamine receptors. Intraperitoneal injection of another DßHI, methimazole, in normal rats also produced hypothermia which was significantly reduced by pimozide. These experiments demonstrate that disulfiram is capable of producing hypothermia in the normal rat when it is given systemically. The fact that pimozide significantly reduced the hypothermia induced by disulfiram or methimazole, indicates that this hypothermie response might involve activation of dopamine receptors.