REPRODUCTIVE OUTCOME AFTER ANESTHESIA AND OPERATION DURING PREGNANCY - A REGISTRY STUDY OF 5405 CASES
REPRODUCTIVE OUTCOME AFTER ANESTHESIA AND OPERATION DURING PREGNANCY - A REGISTRY STUDY OF 5405 CASES
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DOI：
10.1016/0002-9378(89)90659-5
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发表时间：
1989-11-01
影响因子：
9.8
通讯作者：
KALLEN, B
中科院分区：
文献类型：
--
作者：
MAZZE, RI;KALLEN, B
为了确定怀孕期间非产科手术后不良生殖结局的风险，我们将 1973 年至 1981 年间瑞典三个卫生保健登记处（医学出生登记处、先天性畸形登记处和医院出院登记处）的数据联系起来。检查的不良结果包括 (1) 先天性异常、(2) 死产婴儿、(3) 168 小时内死亡的婴儿和 (4) 严重畸形的婴儿的发生率。低出生体重和低出生体重。 72万名孕妇中，共进行了5405例手术（手术率0.75%）。接受手术的妇女的后代先天畸形和死产的发生率并未增加。然而，极低和低出生体重婴儿的发生率有所增加；这些都是早产和宫内生长迟缓的结果。活产但 168 小时内死亡的婴儿发生率也有所增加。没有特定类型的麻醉或手术与不良生殖结果发生率增加相关。这些结果的原因尚未确定。
To define the risk of adverse reproductive outcomes after nonobstetric operations during pregnancy, we linked data from three Swedish health care registries, the Medical Birth Registry, the Registry of Congenital Malformations, and the Hospital Discharge Registry, for the years 1973 to 1981. Adverse outcomes examined were the incidences of (1) congenital anomalies, (2) stillborn infants, (3) infants dead at 168 hours, and (4) infants with very low and low birth weights. There were 5405 operations in the population of 720,000 pregnant women (operation rate, 0.75%). The incidences of congenital malformations and stillbirths were not increased in the offspring of women having an operation. However, the incidences of very-low- and low-birth-weight-infants were increased; these were the result of both prematurity and intrauterine growth retardation. The incidence of infants born alive but dying within 168 hours also was increased. No specific types of anesthesia or operation were associated with increased incidences of adverse reproductive outcomes. The cause of these outcomes was not determined.