Alcohol consumption and coronary artery calcium in middle-aged Japanese men
Alcohol consumption and coronary artery calcium in middle-aged Japanese men
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DOI：
10.1016/j.amjcard.2006.01.095
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发表时间：
2006-07-15
影响因子：
2.8
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Okamura, Tomonori;Kadowaki, Takashi;Ueshima, Hirotsugu
流行病学研究已经调查了饮酒和冠状动脉钙化之间的关系，但结果存在争议。此外，大量饮酒的影响还没有得到很好的阐明。在这项研究中，随机抽取了一组年龄在40岁到49岁之间、没有心血管疾病史的日本男性(n=245)，通过电子束计算机断层扫描和饮酒状况来检测冠状动脉钙质(CAQ)。酒精摄入量和CAC之间存在J型关联。大量饮酒者的CAC增加(>；=46g/天)，在调整了其他心血管危险因素后，每天饮酒量=69g的参与者与从不饮酒者相比，CAC显著增加。(C)2006 Elsevier Inc.保留所有权利。
Epidemiologic studies have investigated the relation between alcohol intake and coronary calcification, with controversial results. Furthermore, the influence of heavy drinking has not been well elucidated. In the present study, a random sample of community-based Japanese men aged 40 to 49 years without a history of cardiovascular disease (n = 245) were examined for coronary artery calcium (CAQ determined by electron-beam computed tomography and drinking status. There was a J-shaped association between alcohol intake and CAC. There was an increase of CAC in heavy drinkers (>= 46 g/day), and participants who were drinking >= 69 g/day showed a significant increase in CAC compared with never drinkers after adjusting for other cardiovascular risk factors. (c) 2006 Elsevier Inc. All rights reserved.