Associated risk factors in the early stage of Chick for diabetic retinopathy
Associated risk factors in the early stage of Chick for diabetic retinopathy
复制标题
糖尿病视网膜病变早期的相关危险因素
DOI：
10.1186/s40662-019-0148-z
复制
发表时间：
2019-08-01
期刊：
影响因子：
4.2
通讯作者：
Li, Yingzi
中科院分区：
文献类型：
--
作者：
Tan, Fan;Chen, Qi;Li, Yingzi
背景应用光学相干断层扫描血管造影术（OCT-A）检测2型糖尿病患者黄斑区视网膜毛细血管密度（RCD），并进一步探讨其与糖尿病危险因素的关系。受试者包括无视网膜病变的糖尿病患者（NDR，n= 90只眼）、轻度视网膜病变DR的糖尿病患者（MDR，n= 36只眼）和健康参与者（对照，n= 86只眼）。所有参与者都接受了OCT-A扫描。结果与对照眼相比，NDR组SRCL和DRCL的RCD均明显降低（P<0. 001），MDR组SRCL和DRCL的RCD均明显降低（P <0. 001）。糖尿病患者根据个体风险因素、糖尿病相关并发症和高血糖症进行细分。与健康对照组相比，糖尿病患者SRCL和DRCL的RCD均降低。年龄> 55岁、HbA 1c> 7%的糖尿病患者与年龄<55岁、HbA 1c < 7%的糖尿病患者相比，其DRCL显著降低（P< 0.05）。血尿素氮（BUN）> 8.2 mmol/L的糖尿病患者SRCL和DRCL显著降低，与其他糖尿病患者相比，年龄较大、HbA 1c、LDL-C和BUN水平较高等危险因素与2型糖尿病合并和不合并轻度DR患者RCD降低相关。OCT-A对视网膜毛细血管的损害可能在糖尿病的早期监测中起重要作用。
BackgroundTo investigate the retinal capillary density (RCD) of the macula using optical coherence tomography angiography (OCT-A) in type 2 diabetic patients and to further determine the association with risk factors.MethodsA total of 212 eyes from 212 subjects were recruited; subjects included diabetics with no retinopathy (NDR,n= 90 eyes), diabetics with mild retinopathy DR (MDR,n= 36 eyes), and healthy participants (Control,n= 86 eyes). All participants underwent OCT-A scanning. RCD was quantified by superficial and deep retinal capillary layers (SRCL and DRCL) from OCT-A images.ResultsRCD in SRCL and DRCL was lower in NDR (P< 0.001) as well as in MDR (P< 0.001) when compared with control eyes. Diabetic patients were subdivided according to individual risk factors, complications related to diabetes, and hyperglycemia. Diabetic patients showed lower RCD in both the SRCL and DRCL when compared with healthy controls. Diabetics with age > 55y, HbA1c > 7% had significantly reduced DRCL (P< 0.05) when compared with the other group of diabetics (age < 55y, HbA1c < 7%). Diabetics with a blood urea nitrogen (BUN) > 8.2 mmol/L had significantly reduced SRCL and DRCL when compared to the other group of diabetics.ConclusionsRisk factors including older age, higher level of HbA1c, LDL-C and BUN, were associated with lower RCDs found in type 2 diabetic patients with and without mild DR by OCT-A. The impairment of retinal capillary by OCT-A may play a key role in the early monitoring of management in diabetes.