Cerebrospinal neuron‐specific enolase, S‐100 and myelin basic protein in neurological disorders
Cerebrospinal neuron‐specific enolase, S‐100 and myelin basic protein in neurological disorders
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神经系统疾病中的脑脊神经元特异性烯醇化酶、S-100 和髓磷脂碱性蛋白
DOI：
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发表时间：
1995
影响因子：
3.5
通讯作者：
R. A. Wevers
中科院分区：
文献类型：
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作者：
Karel J.B. Lamers;B.G.M. van Engelen;Fons J. M. Gabreëls;O. Hommes;G. F. Borm;R. A. Wevers
在这项研究中，检查了患有不同神经系统疾病的儿童和成人脑脊液（CSF）中神经元特异性烯醇化酶（NSE）、S-100蛋白（S-100）和髓鞘碱性蛋白（MBP）的水平。我们部门以前的一项研究证明了CSF中这些脑特异性蛋白的年龄相关参考值。比较了17个不同神经系统疾病组与参考组中3种蛋白质的中位浓度水平。MBP值在多发性硬化（MS）、脑血管意外（CVA）、代谢紊乱和感染患者中显著较高。此外，CVA中的S-100和代谢性疾病中的NSE值显著较高。在CVA中，NSE和S-100值与MBP值显著相关，而在MS中NSE和S-100与MBP值无关。
In this study levels of neuron‐specific enolase (NSE), S‐100 protein (S‐100) and myelin basic protein (MBP) in cerebrospinal fluid (CSF) of children and adults with distinct neurological disorders were examined. A previous study from our department demonstrated age related reference values for these brain‐specific proteins in CSF. The median concentration level of the 3 proteins in 17 different neurological disease groups versus the reference group was compared. Significantly higher MBP values were observed in patients with multiple sclerosis (MS), cerebrovascular accident (CVA), metabolic disorder and infection. Furthermore, significantly higher values were demonstrated for S‐100 in CVA and for NSE in metabolic diseases. In CVA, the NSE and S‐100 values were significantly related with MBP values, whereas in MS the NSE and S‐100 were not related with MBP values.