Trabecular bone adaptation to variations in porous-coated implant topology
Trabecular bone adaptation to variations in porous-coated implant topology
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DOI：
10.1016/s0021-9290(96)00106-6
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发表时间：
1997-02-01
影响因子：
2.4
通讯作者：
Goldstein, SA
中科院分区：
文献类型：
--
作者：
Guldberg, RE;Richards, M;Goldstein, SA
在每天24周的压缩负荷后，评估植入犬股骨远端干骺端的多孔涂层钢板植入物附近的骨小梁适合性。体内实验模型向五种不同的压板植入物拓扑结构提供受控载荷，这些压板形状和多孔涂层分布不同。根据每个钢板下骨小梁结构的三维体视学分析和钢板结构刚度的非破坏性力学测试来评估适应性变化。全涂层圆柱板设计在拉伸和压缩方面都具有最高的结构刚度。局部骨小梁形态的改变也被发现明显受平台种植体拓扑的影响。底部表面完全覆盖的圆柱形钢板与底部光滑的圆柱形钢板或完全涂层的圆锥形钢板相比，骨小梁体积和连通性的减少更大。与所有钢板设计相匹配的对侧对照骨体积的比较显示，实验样本的平均骨体积分数、骨小梁板数量和连通性显著降低，但骨小梁板厚度没有变化。此外，显微结构各向异性分析显示，在实验组织中，小梁朝向加载轴重定向了20度或20.2度。这项研究表明，种植体表面多孔涂层附近的骨小梁适应受到局部种植体拓扑结构变化的影响，并为种植体介导微结构适应的具体机制提供了深入的见解。版权所有(C)1996爱思唯尔科学有限公司。
Trabecular bone adaptation adjacent to porous-coated platen implants embedded within canine distal femoral metaphyses was evaluated following 24 weeks of daily compressive loading. The in vivo experimental model delivered controlled loads to five different platen implant topologies with variations in platen shape and porous coating distribution. Adaptive changes were evaluated based on three-dimensional stereological analyses of trabecular bone architecture underneath each platen and non-destructive mechanical tests of platen construct stiffness. Fully coated cylindrical platen designs possessed the highest construct stiffness in both tension and compression. Changes in local trabecular bone morphology were also found to be significantly influenced by platen implant topology. Cylindrical platens with fully coated bottom surfaces were associated with greater decreases in trabecular bone volume and connectivity than cylindrical platens with smooth bottom surfaces or fully coated conical platens. Comparisons to site-matched contralateral control bone volumes across all platen designs indicated significant decreases in the average bone volume fraction, trabecular plate number, and connectivity within experimental samples, but no change in trabecular plate thickness. In addition, analyses of microstructural anisotropy revealed a 20 degrees or 20.2 degrees trabecular reorientation towards the axis of loading in experimental tissue. This study demonstrates that trabecular bone adaptation near porous-coated surfaces is influenced by variations in local implant topology and provides insight into specific mechanisms of implant-mediated microstructural adaptation. Copyright (C) 1996 Elsevier Science Ltd.