Modulation of cardiac function by lipid metabolites.
Modulation of cardiac function by lipid metabolites.
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脂质代谢物调节心脏功能。
DOI：
10.1097/fjc.0b013e31819ea5e9
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发表时间：
2009
影响因子：
3
通讯作者：
Gottlieb,RobertaA
中科院分区：
文献类型：
--
作者：
Gottlieb,RobertaA
我们对细胞内脂质的看法已经从一个组织成双层的被动的、均匀的、惰性的结构元素的概念演变成一个更动态的概念。我们现在了解到，膜脂经历了重塑，其组成可以随着环境的触发而发生实质性的变化，它们是许多关键信号分子的来源，并且它们在脂质双层中的重塑可以影响该膜的生物物理性质的戏剧性变化。在心脏中，膜的完整性对电兴奋性、离子稳态和线粒体功能至关重要，而脂质信号分子调节心脏功能和应激耐受的许多方面。此外，以缺血/再灌注损伤、糖尿病和饮食缺乏/过量为形式的环境应激可改变心肌膜脂类及其代谢物，导致对心脏功能的显著影响。研究人员在脂生物学方面取得了重大进展，对调节脂代谢各个方面的酶学、调控和遗传学的认识日益加深，但治疗干预措施仍处于起步阶段。为了认识到不断增长的知识体系，《心血管药理学杂志》汇编了一系列综述文章，总结了我们对脂质生物学一些最快速发展的方面的知识现状。前2篇综述出现在本期，接下来的3篇综述出现在下个月的期刊上，并提供了关于脂质信号和重塑的深入讨论。我很高兴担任这一评论系列的客座编辑，我非常感谢优秀的作者们为这个令人兴奋的话题准备了深思熟虑和全面的评论。
Our view of lipids within the cell has evolved from a concept of passive, homogeneous, inert structural elements organized into bilayers to a much more dynamic one. We now understand that membrane lipids undergo remodeling, their composition can change substantially in response to environmental triggers, they are a source of numerous critical signaling molecules, and their remodeling within a lipid bilayer can effect dramatic changes in the biophysical properties of that membrane. In the heart, membrane integrity is critical to electrical excitability, ion homeostasis, and mitochondrial function, whereas lipid-signaling molecules regulate many aspects of cardiac function and stress tolerance. Moreover, environmental stresses in the form of ischemia/reperfusion injury, diabetes, and dietary deficiencies/excesses can modify cardiac membrane lipids and their metabolites, leading to significant effects on cardiac function.Researchers are making significant inroads into lipid biology, with a growing appreciation of the enzymology, regulation, and genetics that modulate diverse aspects of lipid metabolism, yet therapeutic interventions are in their infancy. In recognition of the growing body of knowledge, the Journal of Cardiovascular Pharmacology has assembled a series of review articles summarizing our current state of knowledge of some of the most rapidly developing aspects of lipid biology. The first 2 reviews appear in this issue, followed by 3 more in next month’s issue, and provide in-depth discussions of lipid signaling and remodeling. I am pleased to have served as guest editor for this review series, and I am deeply grateful to the superb authors who have prepared thoughtful and comprehensive reviews on this exciting topic.