Diverse visual features encoded in mouse lateral geniculate nucleus.
Diverse visual features encoded in mouse lateral geniculate nucleus.
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DOI：
10.1523/jneurosci.5187-12.2013
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发表时间：
2013-03-13
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影响因子：
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通讯作者：
Niell CM
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文献类型：
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作者：
Piscopo DM;El-Danaf RN;Huberman AD;Niell CM
丘脑对于确定传递到皮层的感觉信息至关重要。在视觉系统中，丘脑外侧膝状核（LGN）通常被认为编码简单的中心-环绕感受野，这些感受野在皮层中组合成更复杂的特征，例如方向和方向选择性。然而，最近的证据表明，一组更加多样化的视网膜神经节细胞投射到 LGN。因此，我们使用多位点细胞外记录来定义小鼠 LGN（一种新兴的视觉处理模型）中代表的视觉特征。除了中心-环绕细胞之外，我们还发现了大量具有更具选择性编码特性的群体，包括方向和方位选择性，以及发出视觉场景中缺乏对比度信号的神经元。方向选择性神经元在与视网膜方向选择性神经节细胞终止区相匹配的区域中富集，这表明它们的调节来源。总之，这些数据表明，鼠标 LGN 包含比当前模型假设的更精细的视觉场景表示。因此，这些发现应该对我们对小鼠视觉皮层中执行的计算的理解产生重大影响。
The thalamus is crucial in determining the sensory information conveyed to cortex. In the visual system, the thalamic lateral geniculate nucleus (LGN) is generally thought to encode simple center-surround receptive fields, which are combined into more sophisticated features in cortex, such as orientation and direction selectivity. However, recent evidence suggests that a more diverse set of retinal ganglion cells projects to the LGN. We therefore used multisite extracellular recordings to define the repertoire of visual features represented in the LGN of mouse, an emerging model for visual processing. In addition to center-surround cells, we discovered a substantial population with more selective coding properties including direction and orientation selectivity, as well as neurons that signal absence of contrast in a visual scene. The direction and orientation selective neurons were enriched in regions that match the termination zones of direction selective ganglion cells from the retina, suggesting a source for their tuning. Together, these data demonstrate that the mouse LGN contains a far more elaborate representation of the visual scene than current models posit. These findings should therefore have a significant impact on our understanding of the computations performed in mouse visual cortex.