EXCITATORY AMINO-ACID REGULATION OF GONADOTROPIN-SECRETION - MODULATION BY STEROID-HORMONES
EXCITATORY AMINO-ACID REGULATION OF GONADOTROPIN-SECRETION - MODULATION BY STEROID-HORMONES
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DOI：
10.1016/0960-0760(92)90436-m
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发表时间：
1992-03-01
影响因子：
4.1
通讯作者：
MAHESH, VB
中科院分区：
文献类型：
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作者：
BRANN, DW;MAHESH, VB
兴奋性氨基酸（EAA）可以有效地调节雄性和猴的促性腺激素分泌。在本研究中，我们研究了EAAs对低雌激素（卵巢切除）和高雌激素（发情前期）背景下雌性大鼠黄体生成素（LH）和卵泡刺激素（FSH）的影响。在卵巢切除的未成熟雌性大鼠中，注射后30 min，N-甲基-D-天冬氨酸（NMDA）抑制LH分泌，但不抑制FSH分泌。与此相反，NMDA强效刺激LH，但不FSH分泌时，发情前期给药的成年雌性大鼠。谷氨酸和红藻氨酸也被发现刺激LH，但不FSH分泌雌激素治疗卵巢切除的未成年大鼠。这项研究表明，EAA的神经传递可能是一个重要的组成部分，在促性腺激素激增的表达和EAA的影响似乎受到性腺类固醇调节。
Excitatory amino acids (EAAs) can potently modulate gonadotropin secretion in the male and monkey. In the present study we examined the effect of EAAs on luteinzing hormone (LH) and follicle-stimulating hormone (FSH) in the female rat under low estrogen (ovariectomized) and high estrogen (proestrus) backgrounds. In ovariectomized immature female rats N-methyl-D-aspartate (NMDA) inhibited LH but not FSH secretion at 30 min post-injection. In contrast, NMDA potently stimulated LH but not FSH secretion when administered on proestrus to adult female rats. Both glutamate and kainate were also found to stimulate LH but not FSH secretion in estrogen-treated ovariectomized immature rats. This study suggests that EAA neurotransmission may be an important component in the expression of gonadotropin surges and that EAA effects appear to be subject to gonadal steroid regulation.