The long-term effect of ovariectomy on the quality and quantity of cortical bone in the young cynomolgus monkey: a comparison of density fractionation and histomorphometric techniques.
The long-term effect of ovariectomy on the quality and quantity of cortical bone in the young cynomolgus monkey: a comparison of density fractionation and histomorphometric techniques.
复制标题
卵巢切除术对幼年食蟹猴皮质骨质量和数量的长期影响：密度分级和组织形态测量技术的比较。
DOI：
10.1016/8756-3282(93)90169-b
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发表时间：
1993
期刊：
影响因子：
4.1
通讯作者：
Grynpas,M
中科院分区：
文献类型：
--
作者：
Lundon,K;Grynpas,M
尽管有大量文献，但人们对卵巢切除术具体影响皮质骨的机制知之甚少。特别是，非人类灵长类动物的骨骼对卵巢来源的性类固醇激素剥夺的敏感性尚不完全清楚。猕猴作为骨骼生物学研究模型的有用性已得到证实（Williams 和 Bowden，1984；Longcope 等，1989；Jayo 等，1990；Mann 等，1990），然而，这些主要代表了对小梁骨动力学而非皮质骨动力学的影响。非人类灵长类动物特别有用，因为它们在分类学上与人类相似。通过这种方式，例如，使用食蟹猴的股骨可以紧密地代表人类承重皮质骨固有的特性，这与其他模型如大鼠（Jee等人，1990；Kalu，1991；Danielsen等人，1992）和狗（Snow等人，1984；Faugere等人，1990）和狗（Snow等人，1984；Faugere等人，1990）相比，在生长特性、内分泌学和皮质骨组织形态。为了了解这些动物组织水平上的骨重塑过程而分析猕猴皮质骨动力学的尝试很少（Burr，1980；Schaffler 和 Burr，1984；Przybeck，1985；Burr 等，1989；Burr，1992）。然而，这些研究一致认为，猕猴的皮质内骨转换相当低，并表明这些灵长类动物可能是表现出低转换特征的人类骨骼疾病的理想模型。年轻的食蟹猴（M fmcicukzris）的生殖生理学在卵巢衍生的性类固醇激素环境（特别是雌二醇和黄体酮）方面与人类雌性非常相似。另外重要的是，猕猴与循环的人类女性具有相似的周期性和荷尔蒙激增的模式（Jewett 等，1972；Bourget 等，1988；Mann 等，1990）。
Despite a large body of literature, little is known about the mechanisms by which ovariectomy specifically affects cortical bone. In particular, the susceptibility of the skeleton of the non-human primate to deprivation of ovarian-derived sex steroid hormones is incompletely understood. The usefulness of the macaque as a model for studies in skeletal biology has been demonstrated (Williams and Bowden, 1984; Longcope et al., 1989; Jayo et al., 1990; Mann et al., 1990) however these largely represent effects on trabecular rather than cortical bone dynamics. Non-human primates are particularly useful because of their taxonomic affinities to humans. In this way, for example, the use of the femur of the cynomolgus monkey can closely represent the properties inherent to human weight-bearing cortical bone which contrasts to other models such as the rat (Jee et al., 1990; Kalu, 1991; Danielsen et al., 1992) and the dog (Snow et al., 1984; Faugere et al., 1990) which have significant shortcomings in terms of growth properties, endocrinology, and cortical bone tissue morphology. Attempts at analyzing cortical bone dynamics in the macaque in order to understand the processes of bone remodeling at the tissue level in these animals are scarce (Burr, 1980, Schaffler and Burr, 1984, Przybeck, 1985; Burr et al., 1989; Burr, 1992). These studies, however, are in agreement that intracortical bone turnover in macaques is quite low, and have suggested that these primates might be ideal models for human skeletal diseases which demonstrate low turnover characteristics.The young cynomolgus (M fmcicukzris) monkey has a reproductive physiology that closely resembles that of the human female in terms of the ovarian derived sex-steroid hormone milieu, particularly estradiol and progesterone. Of additional importance is that the macaque shares a pattern of similar periodicity and hormonal surges with the cycling human female (Jewett et al., 1972; Bourget et al., 1988; Mann et al., 1990).