LOSS OF NEURONS OF ORIGIN OF THE ADRENERGIC PROJECTION TO CEREBRAL-CORTEX (NUCLEUS LOCUS CERULEUS) IN SENILE DEMENTIA
LOSS OF NEURONS OF ORIGIN OF THE ADRENERGIC PROJECTION TO CEREBRAL-CORTEX (NUCLEUS LOCUS CERULEUS) IN SENILE DEMENTIA
复制标题
老年痴呆症中肾上腺素能投射到大脑皮层（脑室核）的起源神经元的缺失
DOI：
10.1212/wnl.32.2.164
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发表时间：
1982-01-01
期刊：
影响因子：
9.9
通讯作者：
ROTH, M
中科院分区：
文献类型：
--
作者：
BONDAREFF, W;MOUNTJOY, CQ;ROTH, M
为了检查老年性痴呆可能与支配大脑皮层的去甲肾上腺素能神经元的损失相关的可能性，使用Quantimet 720图像分析仪来估计临床诊断为老年性痴呆的老年患者的蓝斑核中的神经元的数量。除1例外，所有病例的组织病理学诊断均为阿尔茨海默型老年性痴呆（SDAT）。在一个亚组中，痴呆评分高，死亡年龄相对较低，蓝斑神经元损失约80%。这种神经元的损失表明一组患者大脑皮质的去甲肾上腺素能神经支配不足，这可能代表SDAT的一种变体。
To examine the possibility that senile dementia may be associated with a loss of noradrenergic neurons that innervate the cerebral cortex, a Quantimet 720 image analyzer was used to estimate the number of neurons in the nucleus locus ceruleus in elderly patients with the clinical diagnosis of senile dementia. In all but 1 case the diagnosis was established histopathologically as senile dementia of the Alzheimer type (SDAT). In a subgroup characterized by a high dementia score and relatively young age at death, there was a loss of about 80% of locus ceruleus neurons. This loss of neurons indicates a deficit of noradrenergic innervation to cerebral cortex in a group of patients which may represent a variant of SDAT.