HBV DNA Integration: Molecular Mechanisms and Clinical Implications.
HBV DNA Integration: Molecular Mechanisms and Clinical Implications.
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DOI：
10.3390/v9040075
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发表时间：
2017-04-10
期刊：
影响因子：
--
通讯作者：
Urban S
中科院分区：
文献类型：
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作者：
Tu T;Budzinska MA;Shackel NA;Urban S
慢性乙肝病毒感染是与肝脏相关的发病率和死亡率的主要原因。在感染了乙肝病毒(或密切相关的动物肝炎病毒)的细胞中观察到的一个特殊现象是，宿主细胞基因组中存在病毒DNA整合，尽管这种形式是病毒复制的死胡同。经常发现的病毒DNA的体细胞整合对病毒有进化上的好处；然而，整合的机制、功能和临床意义仍不清楚。在这里，我们回顾了目前关于HBVDNA整合的知识体系，特别关注其分子机制及其临床意义(包括复制非依赖性抗原表达的可能后果及其在肝细胞癌中的可能作用)。HBVDNA的整合可能会影响HBVDNA的复制、持久性和致病机制，因此值得在未来的研究中给予更多的关注。
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in the host cell genome, despite this form being a replicative dead-end for the virus. The frequent finding of somatic integration of viral DNA suggests an evolutionary benefit for the virus; however, the mechanism of integration, its functions, and the clinical implications remain unknown. Here we review the current body of knowledge of HBV DNA integration, with particular focus on the molecular mechanisms and its clinical implications (including the possible consequences of replication-independent antigen expression and its possible role in hepatocellular carcinoma). HBV DNA integration is likely to influence HBV replication, persistence, and pathogenesis, and so deserves greater attention in future studies.