Gender differences in obsessive-compulsive symptom dimensions
Gender differences in obsessive-compulsive symptom dimensions
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DOI：
10.1002/da.20332
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发表时间：
2008-01-01
影响因子：
7.4
通讯作者：
Vallejo, Julio
中科院分区：
文献类型：
--
作者：
Labad, Javier;Menchon, Jose Manuel;Vallejo, Julio
本研究的目的是通过多变量分析评估性别在强迫症症状维度中的作用，同时控制抽动障碍病史和强迫症发病年龄。186名连续门诊患者与DSM-IV诊断强迫症进行了采访。采用Yak-Brown强迫量表（YBOC-S）、YBOC-S症状自评量表、汉密尔顿抑郁焦虑量表对所有患者进行评定。抽动障碍的终生史采用耶鲁抽动严重程度量表的抽动量表部分进行评估。强迫症的发病年龄进行了评估，直接采访。通过逻辑回归进行统计分析，计算每个维度的校正女性：男性比值比（OR）。性别与两个主要强迫症维度之间存在关系：污染/清洁（女性较高;女性：男性OR = 2.02，P = 0.03）和性/宗教（女性较低;女性：男性OR = 0.41，P = 0.03）。我们没有发现性别差异的侵略性/检查，对称性/订购，或囤积尺寸。我们还发现，在对称性/有序性维度上有症状的患者中，抽动障碍病史更多（P < 0.01）。对称性/秩序性和性/宗教性维度与强迫症的早期发病年龄相关（P < 0.05）。性别是一个变量，在强迫症的表达中发挥作用，特别是污染/清洁和性/宗教方面。我们的研究结果强调，需要检查强迫症的尺寸和临床变量之间的关系，如性别，抽搐，发病年龄和疾病的严重程度，以提高识别强迫症亚型。
The aim of our study was to assess the role of gender in OCD symptom dimensions with a multivariate analysis while controlling for history of tic disorders and age at onset of OCD. One hundred and eighty-six consecutive outpatients with a DSM-IV diagnosis of OCD were interviewed. Yak-Brown Obsessive-Compulsive Scale (YBOC-S), YBOC-S Symptom Checklist, and Hamilton Depression and Anxiety Scales were administered to all patients. Lifetime history of tic disorders was assessed with the tic inventory section of the Yale Global Tic Severity Scale. Age at onset of OCD was assessed by direct interview. Statistical analysis was carried out through logistic regression to calculate adjusted female:male odds ratios (OR) for each dimension. A relationship was found between gender and two main OCD dimensions: contamination/cleaning (higher in females; female:male OR = 2.02, P = 0.03) and sexual/religious (lower in females; female:male OR = 0.41, P = 0.03). We did not find gender differences in the aggressive/checking, symmetry/ordering, or hoarding dimensions. We also found a greater history of tic disorders in those patients with symptoms from the symmetry/ordering, dimension (P < 0.01). Both symmetry/ordering and sexual/religious dimensions were associated with an earlier age at onset of OCD (P < 0.05). Gender is a variable that plays a role in the expression of OCD, particularly the contamination/cleaning and sexual/religious dimensions. Our results underscore the need to examine the relationship between OCD dimensions and clinical variables such as gender, tics, age at onset and severity of the disorder to improve the identification of OCD subtypes.