Drug Eluting Embolization Particles for Permanent Contraception.
Drug Eluting Embolization Particles for Permanent Contraception.
复制标题
用于永久避孕的药物洗脱栓塞剂颗粒。
DOI：
10.1021/acsbiomaterials.2c00357
复制
发表时间：
2022-07-11
影响因子：
5.8
通讯作者：
Woodrow, Kim A.
中科院分区：
文献类型：
--
作者：
VanBenschoten, Hannah;Yao, Shan;Jensen, Jeffrey T.;Woodrow, Kim A.
非手术阻断输卵管的医疗技术可以增加获得永久性避孕措施的机会，并解决目前计划生育方面未得到满足的需求。为了通过疤痕组织的形成实现输卵管的完全闭塞，必须首先发生输卵管上皮的急性损伤，然后是持续的、最终是纤维化的炎症反应。在这里，我们开发了基于药物洗脱纤维的微粒，提供可调节的剂量和有效硬化剂的释放。这种制造策略展示了各种物理化学试剂的高度封装性，以及通过利用自由表面静电纺丝产生纤维微粉化材料进行可扩展制造的潜力。对纳米纤维配方的控制，如载药量、药物疏水性、聚合物疏水性和结晶度，允许调节我们的纤维微粒的缓释性能。我们使用新开发和验证的豚鼠避孕模型，在体内评估了各种纤维微粒配方。我们发现，含有强力环素团注的纤维微粒有效地引起了急性创伤，而含有高负荷量苯基苯甲酸酯的纤维微粒则引起了靶器官的持续炎症。这些电纺微粒的效力，以及它们的栓子大小和形状，表明经宫颈分娩后输卵管近端聚集和炎症活动的可能性。
Medical technology that blocks the fallopian tubes nonsurgically could increase access to permanent contraception and address current unmet needs in family planning. To achieve total occlusion of the fallopian tube via scar tissue formation, acute trauma to the tubal epithelium must first occur followed by a sustained and ultimately fibrotic inflammatory response. Here, we developed drug-eluting fiber-based microparticles that provide tunable dose and release of potent sclerosing agents. This fabrication strategy demonstrates high encapsulation of physicochemically diverse agents and the potential for scalable manufacturing by utilizing free-surface electrospinning to generate material for fiber micronization. Manipulation of nanofiber formulation such as drug loading, drug hydrophobicity, polymer hydrophobicity, and crystallinity allowed for modulation of the sustained release properties of our fiber microparticles. We assessed various fibrous microparticle formulations in vivo using a newly developed and validated guinea pig model for contraception. We found that fiber microparticles with bolus release doxycycline effectively elicited acute trauma and those formulated with highly loaded phenyl benzoate caused sustained inflammation in the target organs. The demonstrated potency of these electrospun microparticles, as well as their embolic size and shape, suggests potential for proximal agglomeration and inflammatory activity in the fallopian tubes following transcervical delivery.
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DOI：
10.1016/j.nano.2018.06.005
发表时间：
2018-10
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
Cao S;Jiang Y;Zhang H;Kondza N;Woodrow KA
通讯作者：
Woodrow KA
影响因子：
1.4
作者：
Halverson, Amy
通讯作者：
Halverson, Amy
DOI：
10.1016/s1051-0443(07)61407-9
发表时间：
2001-01-01
影响因子：
2.9
作者：
Caliendo, MV;Lee, DE;Waldman, DL
通讯作者：
Waldman, DL
影响因子：
2.1
作者：
Liechty ER;Bergin IL;Bell JD
通讯作者：
Bell JD
影响因子：
4.8
作者：
Chow, JC;Young, DW;Gusovsky, F
通讯作者：
Gusovsky, F