Auricular transcutaneous electrical nerve stimulation in depressed patients: a randomized controlled pilot study
Auricular transcutaneous electrical nerve stimulation in depressed patients: a randomized controlled pilot study
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抑郁症患者的耳部经皮神经电刺激：随机对照试验研究
DOI：
10.1007/s00702-012-0908-6
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发表时间：
2013-05-01
影响因子：
3.3
通讯作者：
Kraus, Thomas
中科院分区：
文献类型：
--
作者：
Hein, Ernst;Nowak, Magdalena;Kraus, Thomas
侵入性迷走神经刺激已被证明是一种有效的治疗抑郁症发作。最近，一种新的非侵入性的方法刺激迷走神经的外耳道已经提出。在健康受试者中，一个突出的fMRI BOLD信号失活在边缘系统被发现。本试点研究探讨这种新技术的耳经皮电神经刺激抑郁症患者的第一次的影响。共37例患有重性抑郁症的患者被纳入两项随机化假对照添加研究。在2周的持续时间内，患者每周每天刺激5次。在第0天和第14天，评估汉密尔顿抑郁量表（HAMD）和贝克抑郁量表（BDI）。与假治疗的患者相比，电刺激的人在BDI中表现出显着更好的结果。活性药物治疗组的平均降低为12.6（SD 6.0）分，而假手术组为4.4（SD 9.9）分。两组HAMD评分无明显变化。一种新的经皮耳神经刺激技术的抗抑郁作用已被证明是第一次在这个对照试点研究。关于心理测量测试的局限性，技术原因揭盲的风险，以及小样本量，进一步的研究是必要的，以确认目前的结果，并验证tVNS在临床领域的实用性。
Invasive vagus nerve stimulation has been demonstrated to be an effective treatment in major depressive episodes. Recently, a novel non-invasive method of stimulating the vagus nerve on the outer canal of the ear has been proposed. In healthy subjects, a prominent fMRI BOLD signal deactivation in the limbic system was found. The present pilot study investigates the effects of this novel technique of auricular transcutaneous electric nerve stimulation in depressed patients for the first time. A total of 37 patients suffering from major depression were included in two randomized sham controlled add-on studies. Patients were stimulated five times a week on a daily basis for the duration of 2 weeks. On days 0 and 14, the Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI) were assessed. In contrast to sham-treated patients, electrically stimulated persons showed a significantly better outcome in the BDI. Mean decrease in the active treatment group was 12.6 (SD 6.0) points compared to 4.4 (SD 9.9) points in the sham group. HAMD score did not change significantly in the two groups. An antidepressant effect of a new transcutaneous auricular nerve stimulation technique has been shown for the first time in this controlled pilot study. Regarding the limitations of psychometric testing, the risk of unblinding for technical reasons, and the small sample size, further studies are necessary to confirm the present results and verify the practicability of tVNS in clinical fields.