LONG-TERM TREATMENT OF A VIPOMA WITH SOMATOSTATIN ANALOG RESULTING IN REMISSION OF SYMPTOMS AND POSSIBLE SHRINKAGE OF METASTASES
LONG-TERM TREATMENT OF A VIPOMA WITH SOMATOSTATIN ANALOG RESULTING IN REMISSION OF SYMPTOMS AND POSSIBLE SHRINKAGE OF METASTASES
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DOI：
10.1016/s0016-5085(85)80153-0
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
BLOOM, SR
中科院分区：
文献类型：
--
作者：
KRAENZLIN, ME;CHNG, JLC;BLOOM, SR
1例43岁的转移性VIP瘤患者，经常规手术、化疗和肝动脉栓塞术治疗后，因血管活性肠多肽分泌增多而严重腹泻，经SMS201-995治疗14个月。SMS201-995不仅控制了腹泻，没有副作用，而且似乎可能诱导了转移瘤大小的缩小。
A 43-yr-old-man with metastatic VIPoma in whom the conventional measures of surgery, chemotheraphy, and hepatic artery embolization ultimately failed to control his severe diarrhea, resulting from vasoactive intestinal polypeptide hypersecretion, was treated with a new long-acting somatostatin analogue, SMS 201-995, for 14 mo. SMS 201-995 not only controlled the diarrhea without side effects but appeared to have possibly induced a reduction in metastatic tumor size.