The NOW S. pneumoniae urinary antigen test positivity rate 6 weeks after pneumonia onset and among patients with COPD.
The NOW S. pneumoniae urinary antigen test positivity rate 6 weeks after pneumonia onset and among patients with COPD.
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肺炎发病后 6 周以及 COPD 患者中的 NOW 肺炎链球菌尿抗原检测阳性率。
DOI：
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发表时间：
2003
影响因子：
11.8
通讯作者：
Julie M Cook
中科院分区：
文献类型：
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作者：
D. Murdoch;R. Laing;Julie M Cook
给予体重100kg。在10个月期间进行的一系列粪便和痰液样本检查显示无复发，2次粪便培养的阴性结果证实了这一点。患者于1998年9月死于进行性艾滋病毒疾病。这是乌干达首次报告类圆线虫过度感染综合征合并艾滋病。这是令人惊讶的，考虑到大量的农村艾滋病患者容易患上类圆线虫过度感染综合征。虽然这可能与报告的艾滋病和类圆线虫感染之间缺乏联系的情况一致[3]，但调查设施差和缺乏认识是可能解释这一事实的其他因素。治疗类圆线虫过度感染是困难的，特别是在农村地区，那里的药物选择是非常有限的，这一情况很好地说明了这一点。用乌干达农村最常用的驱虫剂甲苯咪唑治疗显然无效。阿苯达唑和单剂量伊维菌素治疗都是暂时有效的清除肠道幼虫。高剂量阿苯达唑治疗播散性疾病的疗效并不比标准剂量好。另一方面，伊维菌素3天疗程导致所有身体部位的幼虫明显清除，导致持续的无幼虫期，直至患者因潜在免疫抑制而死亡。这份报告表明，在乌干达，类圆线虫过度感染综合征确实与艾滋病有关。这也表明，阿苯达唑和单剂量伊维菌素可能是有用的治疗简单的艾滋病相关的类圆线虫感染。然而，在存在播散的情况下，伊维菌素的疗程较长似乎上级。病人粪便中存在类圆线虫和同时存在的胸部症状应促使临床医生检查痰标本中的幼虫。致谢
kilogram of body weight was given. A series of examinations of stool and sputum samples conducted over a 10-month period revealed no recurrence, and this was confirmed by the negative results of 2 stool cultures. The patient died in September 1998 of progressive HIV disease. This is the first report from Uganda of Strongyloides hyperinfection syndrome complicating AIDS. This is surprising, given the large rural population with AIDS who would be susceptible to Strongyloides hyperinfection syndrome. Though this could be in keeping with the reported lack of association between AIDS and Strongyloides infection [3], poor investigative facilities and lack of awareness are other factors that might explain this fact. Treatment of Strongyloides hyperinfection is difficult, especially in a rural setting, where the choice of drugs is severely limited, as was well-illustrated by this case. Treatment with the most common antihelminthic agent available in rural Uganda, mebendazole, was clearly ineffective. Albendazole and single-dose ivermectin therapy were both temporarily effective in clearing intestinal larvae. A higher dosage of albendazole was no better than a standard dosage in treatment of disseminated disease. A 3-day course of therapy with ivermectin, on the other hand, resulted in an apparent clearance of larvae from all body sites, resulting in a sustained larvafree period until the death of the patient due to underlying immunosuppression. This report shows that Strongyloides hyperinfection syndrome does occur in association with AIDS in Uganda. It also suggests that albendazole and single-dose ivermectin may be useful in treatment of uncomplicated AIDS-associated Strongyloides infection. However, in the presence of dissemination, a longer course of ivermectin appears superior. The presence of Strongyloides in a patient’s stool and the concurrent presence of chest symptoms should prompt clinicians to examine sputum samples for larvae. Acknowledgments