Dissecting Candida albicans Infection from the Perspective of C. albicans Virulence and Omics Approaches on Host-Pathogen Interaction: A Review.
Dissecting Candida albicans Infection from the Perspective of C. albicans Virulence and Omics Approaches on Host-Pathogen Interaction: A Review.
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DOI：
10.3390/ijms17101643
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发表时间：
2016-10-18
影响因子：
5.6
通讯作者：
Chong PP
中科院分区：
文献类型：
--
作者：
Chin VK;Lee TY;Rusliza B;Chong PP
念珠菌血流感染仍然是最常见的危及生命的真菌疾病，白色念珠菌占从感染患者中回收的念珠菌分离株的70%至80%。在自然界中，念珠菌属是哺乳动物宿主正常肠道植物群的一部分。然而，一旦宿主免疫系统被削弱或破坏，它们就可以转化为病原体。最近，归因于念珠菌感染的死亡率持续增加，这是由于念珠菌的固有和获得性耐药性、可用抗真菌药物的无效性、繁琐的诊断程序以及免疫功能低下患者的数量增加。采用动物模型，即微型宿主，小鼠和斑马鱼，使我们更接近于解开人类宿主中念珠菌感染的发病机制和复杂性，从而发现生物标志物和鉴定潜在的治疗药物。此外，组学技术的进步提供了一个全面的观点，在一个非目标和非偏见的方式的寄生虫-主机的相互作用。因此，在这篇综述中，我们试图总结过去和现在的里程碑式的发现，在C。白念珠菌的毒力，采用动物模型进行研究。白色念珠菌感染，以及组学技术在念珠菌与宿主相互作用研究中的应用。深入理解宿主防御和发病机制之间的相互作用对于未来更好地设计新的免疫策略至关重要。
Candida bloodstream infections remain the most frequent life-threatening fungal disease, with Candida albicans accounting for 70% to 80% of the Candida isolates recovered from infected patients. In nature, Candida species are part of the normal commensal flora in mammalian hosts. However, they can transform into pathogens once the host immune system is weakened or breached. More recently, mortality attributed to Candida infections has continued to increase due to both inherent and acquired drug resistance in Candida, the inefficacy of the available antifungal drugs, tedious diagnostic procedures, and a rising number of immunocompromised patients. Adoption of animal models, viz. minihosts, mice, and zebrafish, has brought us closer to unraveling the pathogenesis and complexity of Candida infection in human hosts, leading towards the discovery of biomarkers and identification of potential therapeutic agents. In addition, the advancement of omics technologies offers a holistic view of the Candida-host interaction in a non-targeted and non-biased manner. Hence, in this review, we seek to summarize past and present milestone findings on C. albicans virulence, adoption of animal models in the study of C. albicans infection, and the application of omics technologies in the study of Candida–host interaction. A profound understanding of the interaction between host defense and pathogenesis is imperative for better design of novel immunotherapeutic strategies in future.
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