Association of hypoadiponectinemia with impaired vasoreactivity
Association of hypoadiponectinemia with impaired vasoreactivity
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DOI：
10.1161/01.hyp.0000083488.67550.b8
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发表时间：
2003-09-01
期刊：
影响因子：
8.3
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Ouchi, N;Ohishi, M;Matsuzawa, Y
内皮功能障碍是动脉粥样硬化演变过程中的一个重要特征。脂联素是一种脂肪细胞特异性血浆蛋白，具有抗动脉粥样硬化和抗糖尿病的特性。在本研究中，我们研究了脂联素与内皮依赖性血管舒张的关系。我们分析了202例高血压患者的内皮功能，包括未服用任何药物的患者。前臂血流量用应变计体积描记仪测量。血浆脂联素水平在总用药组（r = 0.257, P < 0.001）和非用药组（r = 0.296, P = 0.026）与反应性充血血管扩张剂反应高度相关，但与硝酸甘油诱导的充血不相关，表明脂联素影响内皮依赖性血管舒张。对所有高血压患者数据的多元回归分析显示，血浆脂联素水平与血管扩张剂对反应性充血的反应独立相关。还分析了脂联素敲除（KO）和野生型（WT）小鼠主动脉环的血管反应性。脂联素- ko小鼠与WT小鼠相比，在致动脉粥样硬化饮食4周后出现肥胖、高血糖和高血压。脂联素- ko小鼠与WT小鼠相比，乙酰胆碱对内皮依赖性血管舒张的影响显著降低，但硝普钠对内皮依赖性血管舒张的影响没有显著差异。我们的观察表明，低脂联素血症与内皮依赖性血管松弛受损有关，血浆脂联素水平的测量可能有助于作为内皮功能障碍的标志物。
Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin is an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In the present study, we investigated the relation between adiponectin and endothelium-dependent vasodilation. We analyzed endothelial function in 202 hypertensive patients, including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma adiponectin level was highly correlated with the vasodilator response to reactive hyperemia in the total ( r = 0.257, P < 0.001) and no-medication ( r = 0.296, P = 0.026) groups but not with nitroglycerin-induced hyperemia, indicating that adiponectin affected endothelium-dependent vasodilation. Multiple regression analysis of data from all hypertensive patients revealed that plasma adiponectin level was independently correlated with the vasodilator response to reactive hyperemia. Vascular reactivity was also analyzed in aortic rings from adiponectin-knockout ( KO) and wild-type (WT) mice. Adiponectin-KO mice showed obesity, hyperglycemia, and hypertension compared with WT mice after 4 weeks on an atherogenic diet. Endothelium-dependent vasodilation in response to acetylcholine was significantly reduced in adiponectin-KO mice compared with WT mice, although no significant difference was observed in endothelium-independent vasodilation in response to sodium nitroprusside. Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction.