Associations of Complement Factor H and Smoking with Early Age-Related Macular Degeneration: The ALIENOR Study
Associations of Complement Factor H and Smoking with Early Age-Related Macular Degeneration: The ALIENOR Study
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DOI：
10.1167/iovs.10-6235
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发表时间：
2011-07-01
影响因子：
4.4
通讯作者：
Korobelnik, Jean-Francois
中科院分区：
文献类型：
--
作者：
Delcourt, Cecile;Delyfer, Marie-Noelle;Korobelnik, Jean-Francois
目的。评估补体因子H (CFH) Y402H多态性与吸烟与早期AMD特异性特征（类型、部位和区域）的关系。ALIENOR研究是一项基于人群的年龄相关眼病研究，在波尔多（法国）的963名73岁或以上的居民中进行。从非散光彩色视网膜照片对AMD特征进行分级。采用血中提取的DNA进行CFH Y402H基因分型。统计分析纳入796例资料完整的受试者。CFH CC基因型与晚期新生血管性AMD密切相关（OR, 6.0； 95%可信区间[CI]， 1.5-23.5），但与晚期萎缩性AMD无关（OR, 0.9; 95% CI, 0.2-4.3）。在早期特征中，它与中央软结节（距中央窝500亩内）有关，无论是中等大小（63-125亩；OR, 2.7; 95% CI, 1.5-4.8）还是较大大小（>125亩；OR, 5.9; 95% CI, 2.2-15.7），但与中央周围软结节（距中央窝500-3000亩）无关。它还与中心面积较大的软瘤密切相关（OR, 5.7; 95% CI, 1.7-19.2）。同样，重度吸烟（20包/年）与中枢性大毒瘤（OR, 3.9; 95% CI, 1.6-9.6）和中枢性大毒瘤（OR, 3.5; 95% CI, 1.2-10.0）密切相关，但与中心周围软毒瘤无关。相比之下，CFH CC和吸烟与中心周围色素异常的相关性更强。异常的位置，连同类型和面积，可能被证明是识别晚期AMD高风险受试者的有用信息。（Invest Ophthalmol Vis Sci. 2011;52:5955-5962） DOI: 10.1167/iovs.10-6235
PURPOSE. To assess the associations of complement factor H (CFH) Y402H polymorphism and smoking with specific features of early AMD (type, location, and area).METHODS. The ALIENOR study is a population-based study of age-related eye diseases in 963 residents of Bordeaux (France), aged 73 years or more. AMD features were graded from non-mydriatic color retinal photographs. CFH Y402H was genotyped by using DNA extracted from blood. Statistical analyses included 796 subjects with complete data.RESULTS. CFH CC genotype was strongly associated with late neovascular AMD (OR, 6.0; 95% confidence interval [CI], 1.5-23.5) but not with late atrophic AMD (OR, 0.9; 95% CI, 0.2-4.3). Among early characteristics, it was associated with central soft drusen (within 500 mu m of the fovea), whether of intermediate (63-125 mu m; OR, 2.7; 95% CI, 1.5-4.8), or large (>125 mu m; OR, 5.9; 95% CI, 2.2-15.7) size, but not with pericentral soft drusen (500-3000 mu m from the fovea). It was also strongly associated with a large central area of soft drusen (OR, 5.7; 95% CI, 1.7-19.2). Similarly, heavy smoking (>20 pack-years) was strongly associated with central large drusen (OR, 3.9; 95% CI, 1.6-9.6) and a large central area of drusen (OR, 3.5; 95% CI, 1.2-10.0), but not with pericentral soft drusen. By contrast, both CFH CC and smoking tended to be more strongly associated with pericentral pigmentary abnormalities.CONCLUSIONS. Location of abnormalities, together with type and area, may prove useful for the identification of subjects at high risk for late AMD. (Invest Ophthalmol Vis Sci. 2011;52:5955-5962) DOI: 10.1167/iovs.10-6235