In Vivo Evidence for GABAA Receptor Changes in the Sensorimotor System in Primary Dystonia
In Vivo Evidence for GABAA Receptor Changes in the Sensorimotor System in Primary Dystonia
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DOI：
10.1002/mds.23553
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发表时间：
2011-04-01
影响因子：
8.6
通讯作者：
Perani, Daniela
中科院分区：
文献类型：
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作者：
Garibotto, Valentina;Romito, Luigi M.;Perani, Daniela
背景资料：临床前和临床证据表明，受损的γ-氨基丁酸（GABA）控制，导致感觉运动系统内的去抑制，可能在肌张力障碍中发挥作用。本研究的目的是使用正电子发射断层扫描（PET）和11 C-氟马西尼（一种选择性GABA（A）受体配体）对肌张力障碍患者的GABA能系统进行体内评估。使用简化的参考组织模型测量结合潜力，将9例DYT 1突变携带者和5例散发病例与11例对照进行比较。基于体素的分析显示，在DYT 1携带者和散发患者中，初级运动和运动前皮质、初级和次级躯体感觉皮质以及扣带回的运动成分中，GABA（A）受体表达/亲和力均降低。原发性（遗传性和散发性）肌张力障碍中感觉运动系统中GABA（A）受体的功能障碍支持缺乏GABA能控制可能与肌张力障碍运动的产生相关的观点。(C)2011年运动障碍学会
Background: Preclinical and clinical evidence suggests that impaired gamma-aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and 11 C-flumazenil, a selective GABA(A) receptor ligand.Methods: Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential.Results: Voxel-based analyses showed a reduction in GABA(A) receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus.Conclusions: Dysfunction of GABA(A) receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements. (C) 2011 Movement Disorder Society