Structure and function of the human skin microbiome.
Structure and function of the human skin microbiome.
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DOI：
10.1016/j.tim.2013.10.001
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发表时间：
2013-12
影响因子：
15.9
通讯作者：
Gallo RL
中科院分区：
文献类型：
--
作者：
Schommer NN;Gallo RL
人类皮肤中存在大量不同种类的细菌、真菌和病毒。据报道，这些微生物在个体之间和皮肤上的不同部位之间存在差异。导致皮肤微生物组独特变异性的因素仅部分了解，但结果表明宿主遗传和环境影响起着主要作用。今天，描述皮肤微生物组的数据的稳定积累，加上旨在测试表面微生物生物功能的实验，为人类生理学和皮肤微生物群之间的联系提供了新的见解。这篇综述描述了一些关于皮肤微生物组及其对人类健康影响的当前信息。具体而言，本文旨在总结目前对皮肤上微生物-宿主相互作用的功能的理解，并突出一些独特的功能，区分皮肤病原微生物。
An abundant and diverse collection of bacteria, fungi and viruses inhabit the human skin. These microorganisms have been reported to vary between individuals and between different sites on the skin. The factors responsible for the unique variability of the skin microbiome are only partially understood, but results suggest host genetic and environmental influences play a major role. Today, the steady accumulation of data describing the skin microbiome, combined with experiments designed to test the biological functions of surface microbes, have provided new insights into links between human physiology and skin microbiota. This review describes some of the current information regarding the skin microbiome and their impact on human health. Specifically, this review seeks to summarize the present understanding of the function of microbe–host interactions on the skin and highlight some unique features that distinguish skin commensals from pathogenic microbes.