BETA-ADRENERGIC MODULATION OF HUMAN UPPER INTESTINAL PROPULSIVE FORCES
BETA-ADRENERGIC MODULATION OF HUMAN UPPER INTESTINAL PROPULSIVE FORCES
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DOI：
10.1136/gut.35.10.1356
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发表时间：
1994-10-01
期刊：
影响因子：
24.5
通讯作者：
HEGGIE, L
中科院分区：
文献类型：
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作者：
AHLUWALIA, NK;THOMPSON, DG;HEGGIE, L
已知β肾上腺素受体阻滞剂通过微小改变肠收缩的数量或模式。因此，本研究测试的假设，增加腔内离口推进力可能有助于这种运输加速度。在10名健康志愿者中进行了20项配对研究，根据双盲、随机方案，口服100 mg阿替洛尔（一种选择性β（1）拮抗剂）或匹配的模拟片剂后。使用组合牵引力检测器和压力测量组件测量与肠道收缩相关的牵引事件的发生频率和所施加的推进力。在阿替洛尔之后，注意到每次牵引事件产生的力的一致增加，对于传播收缩平均值（SEM）（12.0（1.8）g对对照组5.9（0.07）g; p < 0.05）和对于静止收缩平均值（11.6（1.4）g对对照组7.0（0.7）g; p < 0.05）。相反，牵引事件的数量没有变化（对照组对阿替洛尔= 1.6（0.3）v 1.64（0.4）/min，用于传播，0.7（0.1）v 0.85（0.16）/min，用于静止收缩; p > 0.05）。β肾上腺素受体阻滞因此增加了肠收缩产生的推进力，这可能是通过消除肠张力的交感神经抑制。
beta Adrenoceptor blockade is known to through the small changing either the number or pattern of intestinal contractions. This study therefore tested the hypothesis that an increase in intraluminal aboral propulsive force may contribute to this transit acceleration. Twenty paired studies were performed, in 10 healthy volunteers, after oral administration of either 100 mg atenolol (a selective beta(1) antagonist) or matched dummy tablets according to a double blind, randomised protocol. The frequency of occurrence of, and the propulsive force exerted by, traction events related to intestinal contractions were measured, using a combined traction force detector and manometry assembly. After atenolol, a consistent increase in the force generated per traction event was noted, both for propagating contractions mean (SEM) (12.0 (1.8) g v control 5.9 (0.07) g; p < 0.05) and for stationary (11.6 (1.4) g v control 7.0 (0.7) g; p < 0.05). In contrast no change in the number of traction events was noted (control v atenolol = 1.6 (0.3) v 1.64 (0.4) per min for propagating and 0.7 (0.1) v 0.85 (0.16) per min for stationary contraction; p > 0.05). beta Adrenoceptor blockade thus increases the propulsive force generated by intestinal contractions, possibly by removing a sympathetic neural inhibition of intestinal tone.