Size-dependent release of fluorescent macromolecules and nanoparticles from radically cross-linked hydrogels
Size-dependent release of fluorescent macromolecules and nanoparticles from radically cross-linked hydrogels
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DOI：
10.1016/j.ejpb.2009.08.011
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发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Tessmar, Joerg K.
中科院分区：
文献类型：
--
作者：
Henke, Matthias;Brandl, Ferdinand;Tessmar, Joerg K.
水凝胶在药物输送和组织工程应用中发挥着重要作用，因为它们具有良好的生物相容性和可变的机械和物理特性，这使得它们能够针对预期用途的许多不同方面进行优化。在这项研究中，我们研究了聚乙二醇（PEG）基水凝胶作为纳米级药物或药物载体（如纳米颗粒）的释放系统的适用性，使用了可完全交联的低聚（聚（乙二醇）富马酸酯）（OPF）和两种交联剂。在交联水凝胶中加入不同大小和物理结构的荧光纳米探针，获得的释放曲线与凝胶的物理性质和化学结构相关，表明释放与所选择的PEG预聚物有很强的依赖性。通过振荡流变学和溶胀实验对制备的水凝胶进行了表征。释放实验以及光漂白后使用荧光恢复的扩散测量表明，通过改变所用PEG分子的分子量，这种类型的水凝胶在制备可调节释放体系方面具有巨大的潜力。(C) 2009 Elsevier B.V.版权所有
Hydrogels play an important role in drug delivery and tissue engineering applications due to their excellent biocompatibility and their variable mechanical and physical properties, which allow their optimization for many different aspects of the intended use. In this study, we examined the suitability of poly(ethylene glycol) (PEG)-based hydrogels as release systems for nanometer-sized drugs or drug carriers, like nanoparticles, using the radically cross-linkable oligo(poly(ethylene glycol)fumarate) (OPF) together with two cross-linking agents. Different fluorescent nanoparticulate probes with respect to size and physical structure were incorporated in the cross-linked hydrogels, and the obtained release profiles were correlated with the physical properties and the chemical structure of the gels, indicating a strong dependence of the release on the chosen PEG prepolymers. The prepared hydrogels were characterized by oscillatory rheometry and swelling experiments. Release experiments as well as diffusion measurements using fluorescence recovery after photobleaching showed the great potential of this type of hydrogels for the preparation of adjustable release systems by altering the molecular weights of the used PEG molecules. (C) 2009 Elsevier B.V. All rights reserved.