3,3-Dibromo-2-trifluoromethyl Acrylic Acid Ethyl Ester: A Versatile Platform for the Stereoselective Preparation of Functionalized- α-Trifluoromethyl α,β-Unsaturated Lactones and Trifluoromethyl Pyrazolinones
3,3-Dibromo-2-trifluoromethyl Acrylic Acid Ethyl Ester: A Versatile Platform for the Stereoselective Preparation of Functionalized- α-Trifluoromethyl α,β-Unsaturated Lactones and Trifluoromethyl Pyrazolinones
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3,3-二溴-2-三氟甲基丙烯酸乙酯：用于立体选择性制备功能化-α-三氟甲基α,β-不饱和内酯和三氟甲基吡唑啉酮的多功能平台
DOI：
10.1039/c6qo00360e
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chiba K
中科院分区：
文献类型：
--
作者：
Mizuta S;Otaki H. Kitamura;K;Nishi K;Watanabe K;Makau J. N;Hashimoto R;Usui T;Chiba K
本文描述了多官能化-α-三氟甲基α，β-不饱和内酯和三氟甲基吡唑啉酮的合成路线的方法。这涉及3，3-二溴-2-三氟甲基丙烯酸乙酯的串联立体选择性官能化和分子内环化反应，以提供用于与芳基硼酸的Suzuki-Miyaura交叉偶联反应的前体。
We herein describe a method for synthetic routes to multi-functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones. This involves a tandem stereoselective functionalization of 3,3-dibromo-2-trifluoromethyl acrylic acid ethyl ester and intramolecular cyclization reaction to afford precursors for a Suzuki–Miyaura cross-coupling reaction with arylboronic acids.