The role of TRADD in death receptor signaling
The role of TRADD in death receptor signaling
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DOI：
10.4161/cc.11.5.19300
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发表时间：
2012-03-01
期刊：
影响因子：
4.3
通讯作者：
Liu, Zhenggang
中科院分区：
文献类型：
--
作者：
Pobezinskaya, Yelena L.;Liu, Zhenggang
TRADD （TNFR1相关死亡结构域蛋白）最初被确定为TNFR1（肿瘤坏死因子受体1）下游信号转导的衔接分子。TNFR1属于所谓的死亡受体（DR）受体家族，根据不同的背景，可以诱导细胞凋亡或增殖，以及NF κ B和MAP激酶的激活。这类受体含有死亡结构域（DD），这是诱导细胞凋亡所必需的。本文综述了DR信号领域的最新进展，特别是TRADD的作用。
TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1). TNFR1 belongs to the so-called death receptor (DR) family of receptors that, depending on the context, can induce either apoptosis or proliferation, as well as NF kappa B and MAP kinase activation. The receptors of this group contain death domain (DD), which is necessary for the induction of apoptosis. This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD.