MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis
MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis
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MicroRNA-130a 在肝细胞癌中下调并与不良预后相关
DOI：
10.1007/s12032-014-0230-2
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发表时间：
2014-10-01
期刊：
影响因子：
3.4
通讯作者：
Yuan, Yunfei
中科院分区：
文献类型：
--
作者：
Li, Binkui;Huang, Pinzhu;Yuan, Yunfei
最近发现microRNA-130 a（miR-130 a）与多种类型的人类癌症的许多关键过程有关。然而，miR-130 a在肝细胞癌（HCC）中的预后价值仍不清楚。本研究旨在探讨miR-130 a在HCC中的表达及其与HCC患者临床特征和预后的关系。采用实时荧光定量PCR（qRT-PCR）检测102例配对HCC及癌旁组织中miR-130 a的表达水平。qRT-PCR结果显示，miR-130 a在肿瘤组织中的表达明显低于癌旁组织（P<0. 001）。相关分析显示miR-130 a表达与性别（P= 0.008）、HBsAg状态（P= 0.038）、肿瘤大小（P= 0.003）和肿瘤淋巴结转移分期（P= 0.029）显著相关。Kaplan-Meier分析显示，miR-130 a低表达患者的总生存率低于miR-130 a高表达患者（log-rankP= 0.007）。多因素考克斯回归分析显示miR-130 a表达是影响总生存期的独立预后因素（风险比2.217; 95% CI 1.103-4.458;P= 0.025）。本研究首次表明，miR-130 a在HCC中的表达显著下调，并与HCC患者的总生存率相关。本研究还提供了证据表明，miR-130 a是一个独立的预后因素，并可作为HCC患者的潜在预后生物标志物。
MicroRNA-130a (miR-130a) has recently been found to be implicated in many critical processes in various types of human cancer. However, the prognostic value of miR-130a in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the expression of miR-130a in HCC and analyzed its association with clinical features and prognosis of HCC patients. We determined the expression level of miR-130a in 102 cases of paired HCC and adjacent non-tumor tissues by quantitative real-time PCR (qRT-PCR). The qRT-PCR results showed that the miR-130a expression was significantly down-regulated in tumor tissues compared with the adjacent non-tumor tissues (P< 0.001). Correlation analysis showed that miR-130a expression was significantly correlated with gender (P= 0.008), HBsAg status (P= 0.038), tumor size (P= 0.003), and tumor-node-metastasis stage (P= 0.029). Kaplan–Meier analysis showed that patients with low miR-130a expression had a poorer overall survival than patients with high miR-130a expression (log-rankP= 0.007). The multivariate Cox regression analysis indicated that miR-130a expression was an independent prognostic factor for overall survival (hazard ratio 2.217; 95 % CI 1.103–4.458;P= 0.025). The present study showed for the first time that miR-130a expression was significantly down-regulated in HCC and associated with overall survival of patients with HCC. The present study also provided evidence that miR-130a was an independent prognostic factor and could serve as a potential prognostic biomarker for patients with HCC.