Flavonoid intake and bone health.
Flavonoid intake and bone health.
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DOI：
10.1080/21551197.2012.698220
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发表时间：
2012
影响因子：
--
通讯作者：
Ronis MJ
中科院分区：
文献类型：
--
作者：
Weaver CM;Alekel DL;Ward WE;Ronis MJ
黄酮类化合物存在于水果和蔬菜、草药和香料、精油和饮料等多种植物性食物中，是除钙和维生素d外最有潜力促进骨骼健康的膳食成分。最近的流行病学研究表明，与一般水果和蔬菜相比，黄酮类化合物与骨骼的关系更强。生物活性类黄酮正在评估其化学抗氧化能力以外的特性，包括抗炎作用。据报道，一些药物通过影响成骨细胞和破骨细胞分化的细胞信号通路来促进骨形成和抑制骨吸收。未来的研究需要确定哪种类黄酮及其代谢物在何种剂量下最有效，以及调节细胞事件的机制，以便确定临床试验的优先顺序。
Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical anti-oxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials.