Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study
Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study
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DOI：
10.1016/j.bbi.2015.09.004
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发表时间：
2016-08-01
影响因子：
15.1
通讯作者：
Riemersma-Van der Lek, Rixt F.
中科院分区：
文献类型：
--
作者：
Haarman, Bartholomeus C. M. ('Benno');Burger, Huibert;Riemersma-Van der Lek, Rixt F.
背景：海马区是双相情感障碍(BD)多个病理生理学学说中涉及的脑区之一，如神经炎症学说、皮质边缘代谢失调学说等。我们用磁共振成像(MRI)和波谱(MRS)对双相情感障碍(BD-I)患者和健康对照组(HCS)的海马体体积和代谢产物进行了比较。我们随后调查了海马体体积和海马体代谢产物是否与小胶质细胞激活相关，并探索了潜在的疾病改变因素是否会影响这些海马体测量，以及这些因素是否与经历过的情绪和功能有关。材料和方法：22例BD-I患者和24例HCS患者被纳入分析。所有受试者都接受了精神病学访谈和核磁共振扫描，包括T1扫描和媒体磁共振波谱(MRS)。用Freesurfer软件进行容量分析。采用LC模型进行MRS定量。14名患者和11名HC的亚组也成功地进行了[C-11]-(R)PK11195神经炎症正电子发射断层扫描。结果：与我们的假设相反，在校正了个体全脑体积差异后，患者的海马体体积没有减少。左侧海马区N-乙酰天冬氨酸(NAA)+N-乙酰天冬氨酸(NAAG)和肌酸(Cr)+磷酸肌酸(Pcr)浓度降低。在左侧海马区的探索性分析中，我们发现小胶质细胞激活与NAA+NAAG浓度呈正相关，酒精使用与NM+NAAG浓度呈正相关，小胶质细胞激活与抑郁评分呈正相关，而Cr+PCr浓度与经历过的职业残疾呈负相关。结论：与HCS患者相比，BD-I患者左侧海马区NAA+NAAG浓度降低，提示该区域神经元完整性降低。此外，我们发现小胶质细胞的激活与体内神经元的完整性呈正相关，对应着分化的小胶质细胞功能，其中一些小胶质细胞诱导细胞凋亡，而另一些小胶质细胞则刺激神经发生。(C)2015 Elsevier Inc.保留所有权利。
Background: The hippocampus is one of the brain regions that is involved in several pathophysiological theories about bipolar disorder (BD), such as the neuroinflammation theory and the corticolimbic metabolic dysregulation theory. We compared hippocampal volume and hippocampal metabolites in bipolar I disorder (BD-I) patients versus healthy controls (HCs) with magnetic resonance imaging (MRI) and spectroscopy (MRS). We post hoc investigated whether hippocampal volume and hippocampal metabolites were associated with microglial activation and explored if potential illness modifying factors affected these hippocampal measurements and whether these were associated with experienced mood and functioning.Materials and methods: Twenty-two BD-I patients and twenty-four HCs were included in the analyses. All subjects underwent psychiatric interviews as well as an MRI scan, including a T1 scan and PRESS magnetic resonance spectroscopy (MRS). Volumetric analysis was performed with Freesurfer. MRS quantification was performed with LC Model. A subgroup of 14 patients and 11 HCs also underwent a successful [C-11]-(R)PK11195 neuroinflammation positron emission tomography scan.Results: In contrast to our hypothesis, hippocampal volumes were not decreased in patients compared to HC after correcting for individual whole-brain volume variations. We demonstrated decreased N-acetylaspartate (NAA) + N-acetyl-aspartyl-glutamate (NAAG) and creatine (Cr) + phosphocreatine (PCr) concentrations in the left hippocampus. In the explorative analyses in the left hippocampus we identified positive associations between microglial activation and the NAA + NAAG concentration, between alcohol use and NM + NAAG concentration, between microglial activation and the depression score and a negative relation between Cr + PCr concentration and experienced occupational disability. Duration of illness associated positively with volume bilaterally.Conclusion: Compared to HCs, the decreased NAA + NAAG concentration in the left hippocampus of BD-I patients suggests a decreased neuronal integrity in this region. In addition we found a positive relation between microglial activation and neuronal integrity in vivo, corresponding to a differentiated microglial function where some microglia induce apoptosis while others stimulate neurogenesis. (C) 2015 Elsevier Inc. All rights reserved.