Multifunctional nano-photosensitizer: A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility
Multifunctional nano-photosensitizer: A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility
复制标题
多功能纳米光敏剂：具有高效光敏性和pH响应性的无载流子聚集诱导发射纳米粒子
DOI：
10.1016/j.cej.2020.124447
复制
发表时间：
2020-06-15
影响因子：
15.1
通讯作者：
Chang, Jin
中科院分区：
文献类型：
--
作者：
Cheng, Guohui;Wang, Hanjie;Chang, Jin
聚集诱导发射光敏剂（AIE-PS）具有很强的光敏性，在有效的肿瘤光动力治疗中表现良好。然而，小分子AIE-PS由于缺乏靶向性而会引起正常细胞的细胞毒性。研究人员使用纳米载体来提高光敏剂的靶向性，减少对正常组织的毒副作用，这也会带来纳米载体的安全性问题。本研究利用两亲性AIE光敏剂（HD-APNNA）自组装制备了一种新型的无载体的pH响应型AIE纳米光敏剂（AIE-NTA）。这种无载体的AIE-peptide克服了纳米载体的安全性问题，并且HD-APNNA的羧基的质子化和去质子化赋予了AIE-peptide pH响应性。同时，AIE-Doppler的ROS产生效率高达56.7%，上级临床常用的光敏剂。结果表明，AIE-BMP 2在白色光（50 mW cm ~（-2））照射下具有明显的光动力学效应。荷瘤小鼠模型表明，AIE-E2能有效地在实体瘤中蓄积并抑制肿瘤生长。本研究为AIE的光动力学治疗提供了一种新的策略和一些有用的信息，为无载体纳米药物的临床应用提供了有益的参考。
Aggregation-induced emission photosensitizers (AIE-PSs) with strong photosensitization perform well in efficient tumor photodynamic therapy. However, small molecule AIE-PSs will cause cytotoxicity of normal cells for the lack of targeting. Researchers used nanocarriers to improve the targeting of photosensitizers and reduce toxic side effects on normal tissues, which would also bring about the safety problems of nanocarriers. In this study, we developed a novel pH-responsive carrier-free AIE nano-photosensitizer (AIE-NPS) self-assembled by amphiphilic AIE photosensitizer (HD-APNNA). This carrier-free AIE-NPS overcomed the safety problems of nanocarriers and the protonation and deprotonation of carboxyl groups of HD-APNNA endowed the AIE-NPS pHresponsibility. Meanwhile, The ROS production efficiency of AIE-NPS is as high as 56.7%, which is superior to the commonly used photosensitizers in clinic. As a result, the AIE-NPS showed a remarkable photodynamic therapeutic effect in vitro under white light (50 mW cm(-2)). The tumor-bearing mice model demonstrated that the AIE-NPS could effectively accumulate in solid tumors and inhibit the growth of tumors. This work provides a novel strategy and some useful information for the AIE photodynamic therapy and benefits for the clinic application of the carrier-free nanodrugs in the future.