Access to exercise and its relation to cardiovascular health and gene expression in laboratory animals.
Access to exercise and its relation to cardiovascular health and gene expression in laboratory animals.
复制标题
实验动物的运动机会及其与心血管健康和基因表达的关系。
DOI：
10.1016/j.lfs.2005.01.036
复制
发表时间：
2005
期刊：
影响因子：
6.1
通讯作者：
Wiley,RonaldL
中科院分区：
文献类型：
--
作者：
Schweitzer,NatalieB;Alessio,HelaineM;Hagerman,AnnE;Roy,Sashwati;Sen,ChandanK;Nagy,Szilvia;Byrnes,RobynN;Philip,BenN;Woodward,JaneL;Wiley,RonaldL
基因与环境的相互作用可影响心血管疾病(CVD)。这项为期16个月的研究调查了与心血管(CV)调节相关的基因是否在以下动物中有不同的表达：1)没有进行体力活动或锻炼(SED)，2)可以进行长达一小时的每周两次活动(PA)，以及3)每隔一天可以进行一次跑轮(EX)。在31,000个基因中，研究了包含44个基因的CV子集。其中10个基因在EX中的表达与SED不同，34个基因在PA中的表达与SED中不同(p<；0.05)。实验组总胆固醇(70±8比101±9 mg dl−1)、甘油三酯(10 4±8比127±4 mg dl−1)、静息收缩压(130±3比141±3−)、平均动脉压(110±2比120±2)和心率(380±6比405±9次/min−1)均低于对照组(P<0.0 5)，但细胞内黏附分子水平无明显差异。Gja1、Fdft1、Edn1、CD36和Hmgb2的平均基因表达在不同的动物中根据体力活动的不同而不同。这些基因分别在心率、胆固醇生物合成、血压、细胞黏附以及转录和神经发生调控中发挥作用。综上所述，共有44个CV基因在SED中的表达与PA和EX不同；SED显示了更多的CVD的生理学证据。
The interaction between genes and environment can influence cardiovascular disease (CVD). This 16 month study investigated if genes associated with cardiovascular (CV) regulation were expressed differently in animals having: 1) no access to physical activity or exercise (SED), 2) access to hour-long, twice weekly activity (PA), and 3) access every-other-day to a running wheel (EX). Out of 31,000 genes, a CV subset comprising 44 genes was investigated. Ten genes from this subset were expressed differently in EX compared with SED, and 34 genes were expressed differently in PA compared with SED (p<0.05). Total cholesterol (70±8 vs. 101±9 mg dl−1), triglycerides (104±8 vs. 127±4 mg dl−1), resting systolic blood pressure (130±3 vs. 141±3 mmHg), mean arterial pressure (110±2 vs. 120±2 mmHg) and heart rate (380±6 vs. 405±9 beats min−1) were lower in EX compared with SED (p<0.05), but intracellular adhesion molecule levels did not differ among groups. Mean gene expressions for Gja1, Fdft1, Edn1, Cd36, and Hmgb2 differed in animals according to access to physical activity. These genes play roles in heart rate, cholesterol biosynthesis, blood pressure, cell adhesion, and transcription and neurogenesis regulation, respectively. In conclusion, a total of 44 CV genes were expressed differently in SED compared to PA and EX; and SED showed more physiological evidence of CVD.