Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging.
Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging.
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DOI：
10.1186/s12880-022-00832-3
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发表时间：
2022-05-29
影响因子：
2.7
通讯作者：
Cao, Dairong
中科院分区：
文献类型：
--
作者：
Yang, Xiefeng;Xing, Zhen;She, Dejun;Lin, Yu;Zhang, Hua;Su, Yan;Cao, Dairong
idh突变星形细胞瘤的准确分级对于制定治疗策略和评估患者预后至关重要。本研究的目的是探讨DWI、SWI和DSC-PWI在idh突变星形细胞瘤分级中的作用。本文回顾性分析了117例idh突变型星形细胞瘤行DWI、SWI和DSC-PWI的病例。评估最小表观扩散系数（ADCmin）、瘤内易感信号强度（ITSS）和最大相对脑血容量（rCBVmax）值。比较2级与3级、3级与4级、2 + 3级与4级肿瘤的ADCmin、ITSS和rCBVmax值。采用Logistic回归、十倍交叉验证和受试者工作特征（ROC）曲线分析评估其诊断效果。与3级肿瘤相比，4级idh突变星形细胞瘤的ADCmin显著降低，rCBVmax显著升高（经校正P < 0.001）。idh突变的3级星形细胞瘤与4级肿瘤相比，ITSS水平显著降低（校正P < 0.001）。idh突变2级和3级星形细胞瘤间ITSS水平差异有统计学意义（P = 0.002）。ADCmin、ITSS和rCBVmax联合使用的2级和3级肿瘤与4级肿瘤分化的AUC最高。ADCmin、rCBVmax和ITSS可用于idh突变型星形细胞瘤的分级。ADCmin、ITSS和rCBVmax联合应用可提高idh突变型星形细胞瘤分级的诊断效能。
The accurate grading of IDH-mutant astrocytoma is essential to make therapeutic strategies and assess the prognosis of patients. The purpose of this study was to investigate the usefulness of DWI, SWI and DSC-PWI in grading IDH-mutant astrocytoma. One hundred and seven patients with IDH-mutant astrocytoma who underwent DWI, SWI and DSC-PWI were retrospectively reviewed. Minimum apparent diffusion coefficient (ADCmin), intratumoral susceptibility signal intensity(ITSS) and maximum relative cerebral blood volume (rCBVmax) values were assessed. ADCmin, ITSS and rCBVmax values were compared between grade 2 vs. grade 3, grade 3 vs. grade 4 and grade 2 + 3 vs. grade 4 tumors. Logistic regression, tenfold cross-validation,and receiver operating characteristic (ROC) curve analyses were used to assess their diagnostic performances. Grade 4 IDH-mutant astrocytomas showed significantly lower ADCmin and higher rCBVmax as compared to grade 3 tumors (adjusted P < 0.001). IDH-mutant grade 3 astrocytomas showed significantly lower ITSS levels as compared with grade 4 tumors (adjusted P < 0.001). ITSS levels between IDH-mutant grade 2 and grade 3 astrocytomas were significantly different (adjusted P = 0.002). Combined the ADCmin, ITSS and rCBVmax resulted in the highest AUC for differentiation grade 2 and grade 3 tumors from grade 4 tumors. ADCmin, rCBVmax and ITSS can be used for grading the IDH-mutant astrocytomas. The combination of ADCmin, ITSS and rCBVmax could improve the diagnostic performance in grading of IDH-mutant astrocytoma.
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IDH突变体弥漫性和变性星形胶质细胞瘤在表现时的年龄相似，而生存的差异很小：谁是谁的评分问题。
影响因子：
12.7
作者：
Reuss DE;Mamatjan Y;Schrimpf D;Capper D;Hovestadt V;Kratz A;Sahm F;Koelsche C;Korshunov A;Olar A;Hartmann C;Reijneveld JC;Wesseling P;Unterberg A;Platten M;Wick W;Herold-Mende C;Aldape K;von Deimling A
通讯作者：
von Deimling A
影响因子：
12.7
作者：
Olar A;Wani KM;Alfaro-Munoz KD;Heathcock LE;van Thuijl HF;Gilbert MR;Armstrong TS;Sulman EP;Cahill DP;Vera-Bolanos E;Yuan Y;Reijneveld JC;Ylstra B;Wesseling P;Aldape KD
通讯作者：
Aldape KD
影响因子：
3.5
作者：
Jain, R.;Gutierrez, J.;Rock, J. P.
通讯作者：
Rock, J. P.
影响因子：
2.7
作者：
Kang, Xiao-wei;Xi, Yi-bin;Guo, Fan
通讯作者：
Guo, Fan
DOI：
10.1056/nejmoa1402121
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cancer Genome Atlas Research Network;Brat DJ;Verhaak RG;Aldape KD;Yung WK;Salama SR;Cooper LA;Rheinbay E;Miller CR;Vitucci M;Morozova O;Robertson AG;Noushmehr H;Laird PW;Cherniack AD;Akbani R;Huse JT;Ciriello G;Poisson LM;Barnholtz-Sloan JS;Berger MS;Brennan C;Colen RR;Colman H;Flanders AE;Giannini C;Grifford M;Iavarone A;Jain R;Joseph I;Kim J;Kasaian K;Mikkelsen T;Murray BA;O'Neill BP;Pachter L;Parsons DW;Sougnez C;Sulman EP;Vandenberg SR;Van Meir EG;von Deimling A;Zhang H;Crain D;Lau K;Mallery D;Morris S;Paulauskis J;Penny R;Shelton T;Sherman M;Yena P;Black A;Bowen J;Dicostanzo K;Gastier-Foster J;Leraas KM;Lichtenberg TM;Pierson CR;Ramirez NC;Taylor C;Weaver S;Wise L;Zmuda E;Davidsen T;Demchok JA;Eley G;Ferguson ML;Hutter CM;Mills Shaw KR;Ozenberger BA;Sheth M;Sofia HJ;Tarnuzzer R;Wang Z;Yang L;Zenklusen JC;Ayala B;Baboud J;Chudamani S;Jensen MA;Liu J;Pihl T;Raman R;Wan Y;Wu Y;Ally A;Auman JT;Balasundaram M;Balu S;Baylin SB;Beroukhim R;Bootwalla MS;Bowlby R;Bristow CA;Brooks D;Butterfield Y;Carlsen R;Carter S;Chin L;Chu A;Chuah E;Cibulskis K;Clarke A;Coetzee SG;Dhalla N;Fennell T;Fisher S;Gabriel S;Getz G;Gibbs R;Guin R;Hadjipanayis A;Hayes DN;Hinoue T;Hoadley K;Holt RA;Hoyle AP;Jefferys SR;Jones S;Jones CD;Kucherlapati R;Lai PH;Lander E;Lee S;Lichtenstein L;Ma Y;Maglinte DT;Mahadeshwar HS;Marra MA;Mayo M;Meng S;Meyerson ML;Mieczkowski PA;Moore RA;Mose LE;Mungall AJ;Pantazi A;Parfenov M;Park PJ;Parker JS;Perou CM;Protopopov A;Ren X;Roach J;Sabedot TS;Schein J;Schumacher SE;Seidman JG;Seth S;Shen H;Simons JV;Sipahimalani P;Soloway MG;Song X;Sun H;Tabak B;Tam A;Tan D;Tang J;Thiessen N;Triche T Jr;Van Den Berg DJ;Veluvolu U;Waring S;Weisenberger DJ;Wilkerson MD;Wong T;Wu J;Xi L;Xu AW;Yang L;Zack TI;Zhang J;Aksoy BA;Arachchi H;Benz C;Bernard B;Carlin D;Cho J;DiCara D;Frazer S;Fuller GN;Gao J;Gehlenborg N;Haussler D;Heiman DI;Iype L;Jacobsen A;Ju Z;Katzman S;Kim H;Knijnenburg T;Kreisberg RB;Lawrence MS;Lee W;Leinonen K;Lin P;Ling S;Liu W;Liu Y;Liu Y;Lu Y;Mills G;Ng S;Noble MS;Paull E;Rao A;Reynolds S;Saksena G;Sanborn Z;Sander C;Schultz N;Senbabaoglu Y;Shen R;Shmulevich I;Sinha R;Stuart J;Sumer SO;Sun Y;Tasman N;Taylor BS;Voet D;Weinhold N;Weinstein JN;Yang D;Yoshihara K;Zheng S;Zhang W;Zou L;Abel T;Sadeghi S;Cohen ML;Eschbacher J;Hattab EM;Raghunathan A;Schniederjan MJ;Aziz D;Barnett G;Barrett W;Bigner DD;Boice L;Brewer C;Calatozzolo C;Campos B;Carlotti CG Jr;Chan TA;Cuppini L;Curley E;Cuzzubbo S;Devine K;DiMeco F;Duell R;Elder JB;Fehrenbach A;Finocchiaro G;Friedman W;Fulop J;Gardner J;Hermes B;Herold-Mende C;Jungk C;Kendler A;Lehman NL;Lipp E;Liu O;Mandt R;McGraw M;Mclendon R;McPherson C;Neder L;Nguyen P;Noss A;Nunziata R;Ostrom QT;Palmer C;Perin A;Pollo B;Potapov A;Potapova O;Rathmell WK;Rotin D;Scarpace L;Schilero C;Senecal K;Shimmel K;Shurkhay V;Sifri S;Singh R;Sloan AE;Smolenski K;Staugaitis SM;Steele R;Thorne L;Tirapelli DP;Unterberg A;Vallurupalli M;Wang Y;Warnick R;Williams F;Wolinsky Y;Bell S;Rosenberg M;Stewart C;Huang F;Grimsby JL;Radenbaugh AJ;Zhang J
通讯作者：
Zhang J