Identification of Evidence-Based Biospecimen Quality-Control Tools A Report of the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group
Identification of Evidence-Based Biospecimen Quality-Control Tools A Report of the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group
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DOI：
10.1016/j.jmoldx.2012.06.008
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发表时间：
2013-01-01
影响因子：
4.1
通讯作者：
Chuaqui, Rodrigo
中科院分区：
文献类型：
--
作者：
Betsou, Fotini;Gunter, Elaine;Chuaqui, Rodrigo
与处理相关的生物样本质量控制是生物样本科学的目标之一。然而，关于最佳样品质量控制（QC）工具（即标记物和测定）的共识正在形成。本综述的目的是根据全面和关键的文献综述，确定用于液体和固体组织样本的QC工具。最容易适用的工具是那些具有已知的分析前变异阈值和已知的QC分析物参考范围的工具。只有少数有意义的标志物符合这些标准，如CD 40 L用于评估高温下的血清暴露和VEGF用于评估血清冻融。为了全面评估生物样本质量，需要多个QC标记物。在这里，我们提出了最有前途的生物标本质量控制工具，已确定。（J Mal Diagn 2013，15：3-16; http：//dx.doi.org/10.1016/j.jmoldx.2012.06.008）
Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is tacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified. (J Mal Diagn 2013, 15: 3-16; http://dx.doi.org/10.1016/j.jmoldx.2012.06.008)