An investigation into factors associated with Helicobacter pylori infection
An investigation into factors associated with Helicobacter pylori infection
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DOI：
10.1016/s0895-4356(99)00171-7
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发表时间：
2000-02-01
影响因子：
7.2
通讯作者：
McColl, K
中科院分区：
文献类型：
--
作者：
Woodward, M;Morrison, C;McColl, K
这项研究的目的是估计幽门螺杆菌在格拉斯哥的患病率。并提供与这种流行有关的因素的系统分析。所使用的数据来自1995年对年龄在25-64岁之间的793名男性和838名女性的随机抽样。患病率估计为66%(95%置信区间：63-68%)，这一水平在发展中国家更为典型。患病率随年龄和社会剥夺而增加（P < 0.0001），男性略高于女性（P = 0.07）。在对年龄、社会阶层和性别群体进行调整后，幽门螺杆菌患病率随着可替宁（烟草消费量）的增加（P = 0.0005）、兄弟姐妹数量的增加（P < 0.0001）和身高的降低（P = 0.03）而增加。冠心病、高血压、糖尿病、间歇性跛行、饮酒、纤维蛋白原、血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯、婚姻状况、收缩压和舒张压的患病率无独立相关性。在贫困、相对拥挤的儿童生活条件下，这种感染似乎更容易传播。与吸烟的独立关系表明，在晚年可能是感染传播的第二个来源。格拉斯哥高度的社会剥夺被认为是高ii的主要解释。在那里发现了幽门螺杆菌的患病率。(C) 2000 Elsevier Science Inc.；版权所有。
This study aims to estimate the prevalence of Helicobacter pylori in Glasgow. and to provide a systematic analysis of factors associated with this prevalence. The data used are from a random population sample of 793 men and 838 women aged 25-64 years conducted in 1995. The prevalence is estimated to be 66% (95% confidence interval: 63-68%): a level that is more typical of developing countries. Prevalence increases with age and social deprivation (P < 0.0001) and is slightly higher in men than women (P = 0.07). After adjustment for age, social class, and sex group, H. pylori prevalence increases with increased cotinine (tobacco consumption) (P = 0.0005), increased number of siblings (P < 0.0001), and decreased height (P = 0.03). Prevalence of coronary heart disease, hypertension, diabetes and inter mittent claudication, alcohol consumption, fibrinogen, total serum cholesterol, HDL cholesterol, triglycerides, marital status, systolic and diastolic blood pressure had no independent association. The infection seems to be spread more readily in deprived, relatively crowded living conditions in childhood. The independent relationship with smoking suggests a possible second source of spread of infection in later years. The high degree of social deprivation in Glasgow is suggested as a major explanation of the high ii. pylori prevalence found there. (C) 2000 Elsevier Science Inc. All rights reserved.