PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED
PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED
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DOI：
10.1016/j.archger.2009.09.018
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Gambassi, G.
中科院分区：
文献类型：
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作者：
Gambassi, G.
抑郁个体的疼痛患病率和疼痛患者的抑郁患病率高于单独考虑这些情况时的患病率。当疼痛严重、损害功能和/或难以治疗时，它与更多的抑郁症状和更差的抑郁结局相关。同样，疼痛患者的抑郁症与更多的投诉和更大的功能障碍有关。疼痛的缓解是否有助于抑郁症状，或者同样地，抑郁的缓解是否改善了疼痛，这些问题仍然没有完全澄清。然而，越来越多的证据表明，抑郁症和疼痛共享遗传因素，生物途径和神经递质。因此，未来最有前途的研究领域是阐明与抑郁症相关的疼痛通路的神经生物学改变。
The prevalence of pain in depressed individuals and the prevalence of depression in patients with pain are higher than when these conditions are considered individually. When pain is severe, impairs function, and/or is refractory to treatment, it is associated with more depressive symptoms and worse depression outcomes. Similarly, depression in patients with pain is associated with more complaints and greater functional impairment. Whether alleviation of pain helps depressive symptoms or, likewise, whether relief of depression improves pain, are questions still incompletely clarified. However, there is growing evidence that depression and pain share genetic factors, biological pathways and neurotransmitters. Thus, the most promising area of future research is elucidating the neurobiological alterations in pain pathways that intersect with those involved in depression.