Quantification of volumetric coronary blood flow with dual-energy digital subtraction angiography
Quantification of volumetric coronary blood flow with dual-energy digital subtraction angiography
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DOI：
10.1161/01.cir.93.10.1919
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发表时间：
1996-05-15
期刊：
影响因子：
37.8
通讯作者：
Leung, CY
中科院分区：
文献类型：
--
作者：
Molloi, S;Ersahin, A;Leung, CY
背景：为了解决冠状动脉造影图像的视觉判读问题，人们正在研究更多的生理学方法来评估冠状动脉狭窄。容积冠状动脉血流量（BF）可以是一个有价值的援助，在分析的功能意义的动脉objectives.Methods和结果的左前降支冠状动脉（LAD）的15只麻醉猪（40至50公斤）被解剖的心外膜在其近端部分，和一个渡越时间超声流量探头的适当大小。将血管封堵器定位在流量探针的远端以进行流量调节。在使用运动免疫双能量数字减影血管造影（DE DSA）系统进行图像采集期间，向左冠状动脉主干注射造影剂（2至4 mL/s，持续3秒）。组织抑制能量减影图像用于生成时间-密度曲线。使用时间-密度曲线在LAD血管床中进行BF测量，考虑到在注射期间血液被造影剂暂时替代。在19项比较中，使用DE DSA测量的平均BF与平均超声流量相关性非常好（DE DSA = 0.90超声+ 3.10 mL/min，r = 0.96）。此外，造影剂注射增加BF的平均只有15%，在图像采集时间interval.Conclusions准确BF测量可以与运动免疫DE DSA。可以在造影剂注射导致BF发生显著变化之前完成BF测量。此外，在常规冠状动脉造影期间进行BF测量是可能的。
Background As a solution to the well-documented problems associated with visual interpretation of coronary arteriograms, more physiological methods of assessing coronary artery stenosis are being investigated. Volumetric coronary blood flow (BF) can be a valuable aid in the analysis of functional significance of arterial obstruction.Methods and Results The left anterior descending coronary artery (LAD) of 15 anesthetized pigs (40 to 50 kg) was dissected free from the epicardium in its proximal portion, and a transit-time ultrasound flow probe of the appropriate size was applied. A vascular occluder was positioned distal to the flow probe for flow adjustments. Contrast injections (2 to 4 mL/s for 3 seconds) were made into the left main coronary artery during image acquisition with a motion-immune dual-energy digital subtraction angiography (DE DSA) system. Tissue-suppressed energy-subtracted images were used to generate time-density curves. BF measurements were made in the LAD vascular bed with use of the time-density curve, with consideration that blood was momentarily replaced with contrast during the injection. In 19 comparisons, the mean BF, measured with the use of DE DSA, correlated extremely well with the mean ultrasound flow (DE DSA = 0.90 ultrasound + 3.10 mL/min, r = .96). Also, contrast injection increased the BF by an average of only 15% during the image-acquisition time interval.Conclusions Accurate BF measurements can be made with motion-immune DE DSA. The BF measurements can be completed before the onset of significant changes in BF due to contrast injection. Furthermore, it is possible to make the BF measurements during routine coronary arteriography.